Comparative study of serum lactic acid, lactate dehydrogenase and lipid profile in ischemic heart disease patients and healthy control

Abstract EN

The term ischemic heart disease (IHD) defines a disease sp ectrum of diverse etiology, with the common factor being on imbalance between myocardial oxygen supp ly and demand .

Fifty patients (30 male and 20 female) attending Ibn- Al- betar cardic center, the mean age of male was 65 years and 58 y ears for female were included in the present study , Thirty healthy subjects ( 15 male and 15 female ) of matched age were used as control group s.

Some biochemical parameters including lipid and lipoprotein, total cholesterol (TC) , triglycerides (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL), in addition to lactic acid and lactate dehydrogenase (LDH) activities , were evaluated in the sera of IHD patient groups and control group .

The results indicate a significant increase in all parameters except HDL which showed a significant decrease in the sera of male and female patient group s compared with matched sex and age control group.

The results indicate the importance of using the above p arameters as risk factors in addition to new biomarkers for differential dignosis and evaluation of the severity of IHD.