Chronic kidney disease and risk of coronary artery disease : a prospective study

Abstract EN

Background: Reduced glomeular filtration rate is associated with increased morbidity in patients with coronary artery disease.

Objectives : To analyze the declining eGFR and mortality risks in a patients with Chronic Kidney Disease and have had Coronary Artery Disease including risk factors .

Patients and Methods : The study included (160) patients between the ages of 16 and 87years.

Glomerular filtration rate was estimated (eGFR) using the Modification of Diet in Renal Disease equation and was categorized in the ranges <60 mL · min−1 per 1.73 m2 and ≥ 60 ml/min/1.73 m2.

Baseline risk factors were analyzed by category of eGFR,.The studied patients in emergency department, were investigated using Cox proportional hazard models adjusting for traditional risk factors.

Results: The study included (106) male (54) and female (52) between the ages of 16 and 87Years mean age (54.9±15.2).

The eGFR data are calculated for all randomized studied Patients eGFR <60ml/min/1.73 m2 87 (82%), and group of patients with eGFR ≥60ml/min/1.73 m2 19(18%).

Overall there was (44) death 42% mortality risk.

Patients with eGFR ≥60 ml/min/1.73m2 19(18%), positive history of (CAD) is 3 (15.8%) and negative history of (CAD) is16 (84.2%, P=0.0001).

group with reduced eGFR <60 ml/min/1.73 m2 and positive history of (CAD) 42(48.2%), and with negative history is 45(51.8%).

In eGFR ≥60ml/min/1.73 m2 group and positive history of (CAD), the mortality rate is2 (10.5%) and in negative history (CAD) group is 17 (89.5%) Conclusion: This study concluded that impaired GFR, in an adult population, is independently associated with significant levels of increased risk of mortality of fatal and nonfatal coronary events ,e GFR change over time adds prognostic information to traditional mortality risk predictors among patients with chronic kidney disease