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Clinical significance of immunophenotypic markers in pediatric T-cell acute lymphoblastic leukemia
Joint Authors
Hamdi, Nayyirah
Izzat, Samirah
Shaban, Khalid
Sulayman, Suniya
al-Anwar, Wafa
Salim, Shirin
Hassanin, Hala
Mansur, Muhammad Tariq
Yasin, Dina
Sidhum, Iman
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 20, Issue 2 (30 Jun. 2008), pp.111-120, 10 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2008-06-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Topics
Abstract EN
Background : Cell-marker profiling has led to conflicting conclusions about its prognostic significance in T-ALL.
Aim : To investigate the prevalence of the expression of CD34, CD10 and myeloid associated antigens (CD13/ CD33) in childhood T-ALL and to relate their presence to initial clinical and biologic features and early response to therapy.
Patients and Methods : This study included 67 consecutive patients with newly diagnosed T-ALL recruited from the Children's Cancer Hospital in Egypt during the time period from July 2007 to June 2008.
Immunophenotypic markers and minimal residual disease (MRD) were studied by five-color flow cytometry.
Results : The frequency of CD34 was 34.9%, CD10 33.3%, while CD13/CD33 was 18.8%.
No significant association was encountered between CD34, CD10 or myeloid antigen positivity and the presenting clinical features as age, sex, TLC and CNS leukemia.
Only CD10+ expression had significant association with initial CNS involvement (p=0.039).
CD34 and CD13/CD33 expression was significantly associated with T-cell maturation stages (p<0.05).
No relationship was observed for age, TLC, gender, NCI risk or CNS involvement with early response to therapy illustrated by BM as well as MRD day 15 and day 42.
CD34+, CD13/CD33+ and early T-cell stage had high MRD levels on day 15 that was statistically highly significant (p<0.01), but CD10+ had statistically significant lower MRD level on day 15 (p=0.049).
However, only CD34 retained its significance at an MRD cut-off level of 0.01%.
Conclusion : CD34, CD10, CD13/CD33 expression, as well as T-cell maturation stages, may have prognostic significance in pediatric T-ALL as they have a significant impact on early clearance of leukemic cells detected by MRD day 15.
American Psychological Association (APA)
Sidhum, Iman& Shaban, Khalid& Sulayman, Suniya& Izzat, Samirah& al-Anwar, Wafa& Hamdi, Nayyirah…[et al.]. 2008. Clinical significance of immunophenotypic markers in pediatric T-cell acute lymphoblastic leukemia. Journal of the Egyptian National Cancer Institute،Vol. 20, no. 2, pp.111-120.
https://search.emarefa.net/detail/BIM-355823
Modern Language Association (MLA)
Sidhum, Iman…[et al.]. Clinical significance of immunophenotypic markers in pediatric T-cell acute lymphoblastic leukemia. Journal of the Egyptian National Cancer Institute Vol. 20, no. 2 (Jun. 2008), pp.111-120.
https://search.emarefa.net/detail/BIM-355823
American Medical Association (AMA)
Sidhum, Iman& Shaban, Khalid& Sulayman, Suniya& Izzat, Samirah& al-Anwar, Wafa& Hamdi, Nayyirah…[et al.]. Clinical significance of immunophenotypic markers in pediatric T-cell acute lymphoblastic leukemia. Journal of the Egyptian National Cancer Institute. 2008. Vol. 20, no. 2, pp.111-120.
https://search.emarefa.net/detail/BIM-355823
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 119-120
Record ID
BIM-355823