Curcumin attenuates methotraxate-induced hepatic oxidative damage in rats
Joint Authors
Hamidah, Ramadan A. M.
Muhafiz, Umar M.
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 20, Issue 2 (30 Jun. 2008), pp.141-148, 8 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2008-06-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Topics
Abstract EN
In the present study, we have addressed the ability of curcumin to suppress MTX-induced liver damage.
Hepatotoxicity was induced by injection of a single dose of MTX (20mg/kg I.P.).
MTX challenge induced liver damage that was well characterized histopathologically and biochemically.
MTX increased relative liver/body weight ratio.
Histologically, MTX produced fatty changes in hepatocytes and sinusoidal lining cells, mild necrosis and inflammation.
Biochemically, the test battery entailed elevated activities of serum ALT and AST.
Liver activities of superoxide dismutase (SOD), catalase (CAT) and level of reduced glutathione (GSH), were notably reduced, while lipid peroxidation, expressed as malondialdhyde (MDA) level was significantly increased.
Administration of curcumin (100mg/kg, I.P.) once daily for 5 consecutive days after MTX challenge mitigated the injurious effects of MTX and ameliorated all the altered biochemical parameters.
These results showed that administration of curcumin decreases MTX-induced liver damage probably via regulation of oxidant/anti-oxidant balance.
In conclusion, the present study indicates that curcumin may be of therapeutic benefit against MTX-cytotoxicity.
American Psychological Association (APA)
Hamidah, Ramadan A. M.& Muhafiz, Umar M.. 2008. Curcumin attenuates methotraxate-induced hepatic oxidative damage in rats. Journal of the Egyptian National Cancer Institute،Vol. 20, no. 2, pp.141-148.
https://search.emarefa.net/detail/BIM-355835
Modern Language Association (MLA)
Hamidah, Ramadan A. M.& Muhafiz, Umar M.. Curcumin attenuates methotraxate-induced hepatic oxidative damage in rats. Journal of the Egyptian National Cancer Institute Vol. 20, no. 2 (Jun. 2008), pp.141-148.
https://search.emarefa.net/detail/BIM-355835
American Medical Association (AMA)
Hamidah, Ramadan A. M.& Muhafiz, Umar M.. Curcumin attenuates methotraxate-induced hepatic oxidative damage in rats. Journal of the Egyptian National Cancer Institute. 2008. Vol. 20, no. 2, pp.141-148.
https://search.emarefa.net/detail/BIM-355835
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 147-148
Record ID
BIM-355835