Late response to rituximab in a dialysis patient with severe lupus nephritis
Joint Authors
Mooij, Jaap M.
Damardash, Tariq M.
Husayn, Majdi M.
al-Maliki, Najla
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 24, Issue 5 (30 Sep. 2013), pp.976-980, 5 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2013-09-30
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Topics
Abstract EN
Although recently completed controlled trials failed to demonstrate a significant effect of rituximab on the clinical outcome in non-renal and renal lupus, there is growing evidence from case reports and open-label trials that the use of this medication is successful in certain subgroups of patients including refractory cases and helps in reducing the dose of steroids.
We present a 26-year-old female who failed to respond to a long-course treatment with prednisolone, cyclophosphamide, mycophenolate mofetil and azathioprine and who went on to develop end-stage renal disease requiring commencement of regular maintenance hemodialysis.
Ten days before starting dialysis, she was given rituximab, and a second dose was given 17 days after starting dialysis.
After 7 months on dialysis, the patient began to regain kidney function and is now off dialysis for 11 months.
To the best of our knowledge, this is the first case report of a lupus patient on dialysis treated with rituximab in whom dialysis could be stopped and who remained off this therapy up till now, after an observation period of 1 year.
American Psychological Association (APA)
Husayn, Majdi M.& Mooij, Jaap M.& al-Maliki, Najla& Damardash, Tariq M.. 2013. Late response to rituximab in a dialysis patient with severe lupus nephritis. Saudi Journal of Kidney Diseases and Transplantation،Vol. 24, no. 5, pp.976-980.
https://search.emarefa.net/detail/BIM-355891
Modern Language Association (MLA)
Mooij, Jaap M.…[et al.]. Late response to rituximab in a dialysis patient with severe lupus nephritis. Saudi Journal of Kidney Diseases and Transplantation Vol. 24, no. 5 (2013), pp.976-980.
https://search.emarefa.net/detail/BIM-355891
American Medical Association (AMA)
Husayn, Majdi M.& Mooij, Jaap M.& al-Maliki, Najla& Damardash, Tariq M.. Late response to rituximab in a dialysis patient with severe lupus nephritis. Saudi Journal of Kidney Diseases and Transplantation. 2013. Vol. 24, no. 5, pp.976-980.
https://search.emarefa.net/detail/BIM-355891
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 979-980
Record ID
BIM-355891