Total sialic acid concentrations as a supporting marker of malignancy in acute lymphoblastic leukemia

Abstract EN

To follow up the response of aeutc lymphoblastic leukemic (ALL) patients to chemotherapy treatment and for prognosis, diagnosis, the total Sialic acid (TSA) levels was studied as a tumor marker.

The study included 40 patients (male = 22.

female -18) with (ALL) were tested for the* serum and Ictikocytes homogcnate concentrations of total sialic acid (TSA) before and aller treatment with six different chemotherapy protocols, ^'hile significantly increased ( p< 0.001 ) as compared to the healthy individuals grojp.

serum and leukoc؛rtcs homogenate TSA concentrations dropped significantly ( p<0.001) after treatment with each of the six chemotherapy treatment protocols, as compared to ALL untreated patients.

A linear conflation relationship (r2-0.9514 ; r2 = 0.9451) was found between TSA concentrations and the period of chemotherapy treatment in senim and leukocyte؛؛ homogenate.

A linear correlation relationship (r2 = 0.9965) could be found between percentage of serum total sialic acid and percentage of leukocytes homogenate total siahc acid, rile results of this study strongly support the role ofTSA as a marker lor the disease and suggest that it could be used for progression and prognosis of ALL patients, in addition we strongly suggest that the:c was a positive relationship between TSA level in serum and leukocytes.