Expression of CD44 and P53 in renal cell carcinoma : association with tumor subtypes
Joint Authors
Rasmi, Yusuf
Noroozinia, Farahnaz
Fahmideh, Abbas Naddaf
Yekta, Zahrah
Rouhrazi, Hadi
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 25, Issue 1 (28 Feb. 2014), pp.79-84, 6 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2014-02-28
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
Renal cell carcinoma (RCC) is a common malignancy of the kidney and accurate prediction of prognosis is valuable for the design of adjuvant therapy and counseling and effective scheduling of follow-up visits.
Molecular genetic investigations of CD44 and P53 in RCC may be helpful in this regard.
We studied the CD44 and P53 expressions semi-quantitatively on paraffinembedded specimens of 64 RCC patients (37 male/27 female) who underwent surgery from 2003 to 2008 by immunohistochemistry and analyzed the correlation of P53 and CD44 expression in RCC and outcome.
Thirteen of 64 (20.3%) specimens were P53 positive, 30/64 (46.9%) were CD44 positive and five tumors with positive P53 expressed CD44 protein (P = 0.5).
A statistically significant correlation was not found between CD44 and P53 expression (P = 0.5) and age (P = 0.07), sex (P= 0.3), tumor size (P = 0.7), grade (P = 0.23), vascular invasion (P = 1.00) and ureteral invasion (P = 1.00).
Furthermore, a significant correlation was not found between P53 expression with age (P = 0.3), sex (P = 0.7), tumor size (P = 0.7), grade (P = 0.1), vascular invasion (P = 1.00) and ureteral invasion (P = 1.00).
According to our findings, only P53 expression is generally accompanied by non-conventional subtype tumor.
American Psychological Association (APA)
Noroozinia, Farahnaz& Fahmideh, Abbas Naddaf& Yekta, Zahrah& Rouhrazi, Hadi& Rasmi, Yusuf. 2014. Expression of CD44 and P53 in renal cell carcinoma : association with tumor subtypes. Saudi Journal of Kidney Diseases and Transplantation،Vol. 25, no. 1, pp.79-84.
https://search.emarefa.net/detail/BIM-356676
Modern Language Association (MLA)
Noroozinia, Farahnaz…[et al.]. Expression of CD44 and P53 in renal cell carcinoma : association with tumor subtypes. Saudi Journal of Kidney Diseases and Transplantation Vol. 25, no. 1 (Jan. / Feb. 2014), pp.79-84.
https://search.emarefa.net/detail/BIM-356676
American Medical Association (AMA)
Noroozinia, Farahnaz& Fahmideh, Abbas Naddaf& Yekta, Zahrah& Rouhrazi, Hadi& Rasmi, Yusuf. Expression of CD44 and P53 in renal cell carcinoma : association with tumor subtypes. Saudi Journal of Kidney Diseases and Transplantation. 2014. Vol. 25, no. 1, pp.79-84.
https://search.emarefa.net/detail/BIM-356676
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 83-84
Record ID
BIM-356676