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Effects of Melothria maderaspatana leaf extract on antioxidant status in sham-operated and uninephrectomized DOCA-salt hypertensive rats
Joint Authors
Veeramani, Chinnadurai
Aristatile, Balakrishnan
Pushpavalli, Ganesan
Pugalendi, Kodukkur Viswanathan
Source
Saudi Journal of Biological Sciences
Issue
Vol. 18, Issue 1 (31 Mar. 2011), pp.99-105, 7 p.
Publisher
Publication Date
2011-03-31
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
Abstract EN
The present study was designed to investigate the antihypertensive and antioxidant effect of Melothria maderaspatana leaf extract (MME) on sham-operated and DOCA-salt (deoxycorticosterone acetate) induced hypertensive rats.
Administration of DOCA-salt significantly increased the systolic (from 127 to 212 mm Hg) and diastolic (from 91 to 174 mm Hg) blood pressure compared to sham-operated control rats, while treatment with MME significantly reduced the systolic (from 212 to 135 mm Hg) and diastolic (from 174 to 96 mm Hg) blood pressure compared to hypertensive control.
In DOCA-salt rats, the plasma and tissue concentration of thiobarbituric acid reactive substances (TBARS) and lipid hydroperoxide (LOOH) significantly increased and administration of MME significantly reduced these parameters towards the levels in sham-operated control.
In hypertensive rats, activities of the enzymatic antioxidants such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) and levels of non-enzymatic antioxidants such as vitamin C, vitamin E and reduced glutathione (GSH) decreased significantly in the plasma and tissues.
Administration of MME returned the enzymatic and non-enzymatic antioxidants towards shamoperated control.
MME shows both antihypertensive and antioxidant properties in DOCA-salt hypertensive rats and, among the three different doses tested, 200 mg / kg caused the maximum effect.
American Psychological Association (APA)
Veeramani, Chinnadurai& Aristatile, Balakrishnan& Pushpavalli, Ganesan& Pugalendi, Kodukkur Viswanathan. 2011. Effects of Melothria maderaspatana leaf extract on antioxidant status in sham-operated and uninephrectomized DOCA-salt hypertensive rats. Saudi Journal of Biological Sciences،Vol. 18, no. 1, pp.99-105.
https://search.emarefa.net/detail/BIM-357547
Modern Language Association (MLA)
Veeramani, Chinnadurai…[et al.]. Effects of Melothria maderaspatana leaf extract on antioxidant status in sham-operated and uninephrectomized DOCA-salt hypertensive rats. Saudi Journal of Biological Sciences Vol. 18, no. 1 (2011), pp.99-105.
https://search.emarefa.net/detail/BIM-357547
American Medical Association (AMA)
Veeramani, Chinnadurai& Aristatile, Balakrishnan& Pushpavalli, Ganesan& Pugalendi, Kodukkur Viswanathan. Effects of Melothria maderaspatana leaf extract on antioxidant status in sham-operated and uninephrectomized DOCA-salt hypertensive rats. Saudi Journal of Biological Sciences. 2011. Vol. 18, no. 1, pp.99-105.
https://search.emarefa.net/detail/BIM-357547
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 104-105
Record ID
BIM-357547