Protective effect of L-carnitine against acrylamide-induced DNA damage in somatic and germ cells of mice
Author
al-Zahrani, Hind Abd Allah Sayyid
Source
Saudi Journal of Biological Sciences
Issue
Vol. 18, Issue 1 (31 Mar. 2011), pp.29-36, 8 p.
Publisher
Publication Date
2011-03-31
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Topics
Abstract EN
Recent findings of acrylamide (AA) in many common foods have sparked renewed interest in assessing human health hazards.
AA was evaluated by the International Agency for Research on Cancer as probably carcinogenic to humans.
For this reason, the aim of this study is to evaluate the potential genotoxic effect of AA using chromosomal aberration analysis and micronucleus (MN) test in mouse bone-marrow cells and morphological sperm abnormalities.
The result of the present work indicated that treatment with a single dose of 10, 20, or 30 mg / kg b.
wt.
of AA for 24 h and the repeated dose of 10 mg / kg b.wt.
for 1and 2 weeks induced a statistically significant increase in the percentage of chromosomal aberrations and micronuclei in bone-marrow cells.
These percentages reduced significantly in all groups treated with AA and the protective agent Lcarnitine.
Also the results indicated that the dose 10, 20 and 30 mg / kg b.
wt.
of AA induced a statistically significant percentage of morphological sperm abnormalities compared with the control group.
Such effect reached its maximum (7.24 ± 0.61) with the highest tested dose which reduced to (4.02 ± 0.58) in the group treated with the same dose of AA and L-carnitine.
In conclusion, the results confirm the protective role of LC against the mutagenicity of AA.
American Psychological Association (APA)
al-Zahrani, Hind Abd Allah Sayyid. 2011. Protective effect of L-carnitine against acrylamide-induced DNA damage in somatic and germ cells of mice. Saudi Journal of Biological Sciences،Vol. 18, no. 1, pp.29-36.
https://search.emarefa.net/detail/BIM-357556
Modern Language Association (MLA)
al-Zahrani, Hind Abd Allah Sayyid. Protective effect of L-carnitine against acrylamide-induced DNA damage in somatic and germ cells of mice. Saudi Journal of Biological Sciences Vol. 18, no. 1 (2011), pp.29-36.
https://search.emarefa.net/detail/BIM-357556
American Medical Association (AMA)
al-Zahrani, Hind Abd Allah Sayyid. Protective effect of L-carnitine against acrylamide-induced DNA damage in somatic and germ cells of mice. Saudi Journal of Biological Sciences. 2011. Vol. 18, no. 1, pp.29-36.
https://search.emarefa.net/detail/BIM-357556
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 34-36
Record ID
BIM-357556