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Cytogenetic effects of sildenafil citrate (Viagra) on SWR J mouse bone marrow cells
Joint Authors
Abu Tarbush, Faysal Muhammad
Abd al-Samad, Muhammad Fathi
Source
Saudi Journal of Biological Sciences
Issue
Vol. 17, Issue 4 (31 Oct. 2010), pp.315-319, 5 p.
Publisher
Publication Date
2010-10-31
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Topics
Abstract EN
The present study was conducted to investigate the cytogenetic effects of sildenafil citrate in SWR / J mouse bone marrow cells.
Thirty-six males and 36 females were used and divided into four groups.
Each group contained 18 animals (9 males and 9 females), weighing 30–35 g.
These animals were orally administered with a single dose of 13, 26 or 40 mg / kg sildenafil citrate solution.
A control group received normal saline in an identical condition.
The animals were sacrificed at 12, 24 or 48 h, after the treatment.
Chromosome aberrations were investigated in 50 metaphases per animal.
No significant differences in the percentages of mitotic indices or in the frequencies of chromosome aberrations were observed between treated male and female mice at any doses or at any time intervals used, therefore, data from the two sexes were pooled when analyzed statistically.
No significant (p < 0.05) differences in the percentages of mitotic indices or in the frequencies of chromosome aberrations were observed between sildenafil citrate-treated groups and the control group at any doses or at any time intervals used.
However, the percentages of centromeric adhesions increased significantly (p < 0.01) in treated groups as compared with the control group at all doses and at all time intervals used.
In conclusion, the results of the present study suggest that sildenafil citrate does not have cytogenetic effects on mouse bone marrow cells, but the centromeric adhesions induced by this drug need further studies to confirm them and to investigate the possible mechanism (s) responsible for such effect.
American Psychological Association (APA)
Abu Tarbush, Faysal Muhammad& Abd al-Samad, Muhammad Fathi. 2010. Cytogenetic effects of sildenafil citrate (Viagra) on SWR J mouse bone marrow cells. Saudi Journal of Biological Sciences،Vol. 17, no. 4, pp.315-319.
https://search.emarefa.net/detail/BIM-357563
Modern Language Association (MLA)
Abu Tarbush, Faysal Muhammad& Abd al-Samad, Muhammad Fathi. Cytogenetic effects of sildenafil citrate (Viagra) on SWR J mouse bone marrow cells. Saudi Journal of Biological Sciences Vol. 17, no. 4 (Oct. 2010), pp.315-319.
https://search.emarefa.net/detail/BIM-357563
American Medical Association (AMA)
Abu Tarbush, Faysal Muhammad& Abd al-Samad, Muhammad Fathi. Cytogenetic effects of sildenafil citrate (Viagra) on SWR J mouse bone marrow cells. Saudi Journal of Biological Sciences. 2010. Vol. 17, no. 4, pp.315-319.
https://search.emarefa.net/detail/BIM-357563
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 319
Record ID
BIM-357563