Lack of micronuclei formation in bone marrow of rats after oral exposure to thiocyclam insecticide
Joint Authors
Salih, Kamil
Celikler, Sirab
Sarhan, Muhammad A. A.
Source
Saudi Journal of Biological Sciences
Issue
Vol. 17, Issue 4 (31 Oct. 2010), pp.311-314, 4 p.
Publisher
Publication Date
2010-10-31
Country of Publication
Saudi Arabia
No. of Pages
4
Main Subjects
Topics
Abstract EN
In this study, a nereistoxin analogue insecticide, thiocyclam, was administered to adult male albino rats by gavage dose of 135, 270 and 540 mg / kg b.w.
repeated for 5 days at 24 h intervals.
Control animals received only water.
Thiocyclam was tested for its potential to cause genotoxic effects in rat bone marrow cells using an in vivo micronucleus assay.
After 24 h of the last treatment, rats from all dose levels were sacrificed.
Bone marrow cells were collected and assayed for the presence of micronuclei.
Thiocyclam did not cause any increase in the incidence of micronucleated polychromatic erythrocytes in rats bone marrow at any of the dose levels.
The polychromatic erythrocytes / normochromatic erythrocytes (PCE : NCE) ratio was found to be in the range from 0.50 ± 0.11 to 0.55 ± 0.02.
The results of this study demonstrate that the effect of thiocyclam is not significant in the rat in vivo micronucleus assay.
American Psychological Association (APA)
Salih, Kamil& Celikler, Sirab& Sarhan, Muhammad A. A.. 2010. Lack of micronuclei formation in bone marrow of rats after oral exposure to thiocyclam insecticide. Saudi Journal of Biological Sciences،Vol. 17, no. 4, pp.311-314.
https://search.emarefa.net/detail/BIM-357574
Modern Language Association (MLA)
Salih, Kamil…[et al.]. Lack of micronuclei formation in bone marrow of rats after oral exposure to thiocyclam insecticide. Saudi Journal of Biological Sciences Vol. 17, no. 4 (Oct. 2010), pp.311-314.
https://search.emarefa.net/detail/BIM-357574
American Medical Association (AMA)
Salih, Kamil& Celikler, Sirab& Sarhan, Muhammad A. A.. Lack of micronuclei formation in bone marrow of rats after oral exposure to thiocyclam insecticide. Saudi Journal of Biological Sciences. 2010. Vol. 17, no. 4, pp.311-314.
https://search.emarefa.net/detail/BIM-357574
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 314
Record ID
BIM-357574