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Histopathology and cytotoxicity as biomarkers in treated rats with cadmium and some therapeutic agents
Joint Authors
al-Rifi, Amal I.
Eissa, Fawzi I.
Source
Saudi Journal of Biological Sciences
Issue
Vol. 20, Issue 3 (31 Jul. 2013), pp.265-280, 16 p.
Publisher
Publication Date
2013-07-31
Country of Publication
Saudi Arabia
No. of Pages
16
Main Subjects
Topics
Abstract EN
The present study aimed to investigate the protective role of ascorbic acid (vitamin C) and zinc (Zn) against cadmium (Cd) induced histopathological changes in tissues of liver, kidney, lung and testis of rats as well as chromosomal aberrations.
For this purpose, 60 male albino rats were divided into six groups ; each group contained 10 animals.
The first group served as control and was given only distilled water.
The second and third groups received distilled water supplemented with 2 g ascorbic acid/l and 500 mg Zn/l, respectively.
The fourth group received a daily oral dose containing 3 mg Cd / kg b.w.
(1/30 LD50).
The fifth group received Cd+ascorbic acid (3 mg Cd / kg b.w.
+ 2 g ascorbic acid / l), while the sixth group received Cd+ Zn (3 mg Cd / kg b.w.
+500 mg Zn/l).
The treatment in all groups lasted for 90 consecutive days.
Rats exposed to cadmium showed severe histopathological changes in the liver, kidney, lung and testicular tissues as well as chromosomal aberrations such as : break, ring, centromeric separation and polyploidy.
Co-treatment with zinc partially improved the histopathological changes and chromosomal aberrations while co-treatment with vitamin C exhibited a more protective role and markedly reduced tissues damage induced by Cd.
American Psychological Association (APA)
al-Rifi, Amal I.& Eissa, Fawzi I.. 2013. Histopathology and cytotoxicity as biomarkers in treated rats with cadmium and some therapeutic agents. Saudi Journal of Biological Sciences،Vol. 20, no. 3, pp.265-280.
https://search.emarefa.net/detail/BIM-358356
Modern Language Association (MLA)
al-Rifi, Amal I.& Eissa, Fawzi I.. Histopathology and cytotoxicity as biomarkers in treated rats with cadmium and some therapeutic agents. Saudi Journal of Biological Sciences Vol. 20, no. 3 (Jul. 2013), pp.265-280.
https://search.emarefa.net/detail/BIM-358356
American Medical Association (AMA)
al-Rifi, Amal I.& Eissa, Fawzi I.. Histopathology and cytotoxicity as biomarkers in treated rats with cadmium and some therapeutic agents. Saudi Journal of Biological Sciences. 2013. Vol. 20, no. 3, pp.265-280.
https://search.emarefa.net/detail/BIM-358356
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 278-280
Record ID
BIM-358356