Lack of association between TRAF1C5 rs10818488 polymorphism and rheumatoid arthritis in Iranian population

Abstract EN

Rheumatoid arthritis (RA) is a multifactorial disorder related to the inflammatory response system with debilitating and painful conditions.

Both genetic and environmental factors, with unknown etiology, play important roles in this disease pathogenesis.

Recently, TRAF1 / C5 (Tumor Necrosis Factor Receptor-Associated Factor 1 / Complement Component 5) polymorphism associated with increased risk for RA has been studied in different populations worldwide, and inconsistent results have been obtained.

Rs 10818488 allele is located on TRAF1 / C5 intergenic region, and has been predicted to be functional.

A total of 100 sex- and age-matched people including RA patients (n = 50) and healthy individuals (n = 50) from Iran have been entered in this study and genotyped for rs10818488 (A / G) polymorphism, using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP).

In our study, rs10818488 allele was not associated with risk for RA in Iranian population (p > 0.05, OR = 1.27, 95 % CI = 0.72–2.23).

Results revealed that this allele might be population-specific and not to be associated with their corresponding gene pool.

However, further analyses are required to clarify other RA-associated markers in our community.