Changes induces by haloperidol (antidepressant drug) on the developing retina of the chick embryo
Joint Authors
Abd al-Majid, Badriyah Fathi
al-Ghamidi, Fawziyah Abd Allah
Source
Saudi Journal of Biological Sciences
Issue
Vol. 16, Issue 2 (31 Oct. 2009), pp.85-94, 10 p.
Publisher
Publication Date
2009-10-31
Country of Publication
Saudi Arabia
No. of Pages
10
Main Subjects
Topics
Abstract EN
Morphological and histological studies were done on the retina of chick embryos of 6th, 10th and 16th days of incubation by a single dose of haloperidol (0.25 mg / egg), injected on day zero and 5 of incubation.
To get an idea about the extent of the teratogenic effect of this drug on the development retina.
Sign of malformation in the chick embryo after administration of haloperidol were seen as absent of the ear vesicles, eyes or decreased size of them.
Retardation of growth of the retina at 6th, 10th and 16th days treated chick embryo were observed as evidenced of reduction of the size of the retina, associated with sign of degeneration of the retina cells.
Conclusion : The injection of haloperidol drug give rise to several side effects as retardation of growth and degeneration of the cells.
The decrease of the thickness of the layers and less density of the cells was related to direct effect of the drug on the cells of this organ.
Also on the DNA formation and on the retardation of cellular mitotic activates, therefore the retina appeared decrease in thickness and less cell density with degeneration its cells.
American Psychological Association (APA)
Abd al-Majid, Badriyah Fathi& al-Ghamidi, Fawziyah Abd Allah. 2009. Changes induces by haloperidol (antidepressant drug) on the developing retina of the chick embryo. Saudi Journal of Biological Sciences،Vol. 16, no. 2, pp.85-94.
https://search.emarefa.net/detail/BIM-359025
Modern Language Association (MLA)
Abd al-Majid, Badriyah Fathi& al-Ghamidi, Fawziyah Abd Allah. Changes induces by haloperidol (antidepressant drug) on the developing retina of the chick embryo. Saudi Journal of Biological Sciences Vol. 16, no. 2 (Oct. 2009), pp.85-94.
https://search.emarefa.net/detail/BIM-359025
American Medical Association (AMA)
Abd al-Majid, Badriyah Fathi& al-Ghamidi, Fawziyah Abd Allah. Changes induces by haloperidol (antidepressant drug) on the developing retina of the chick embryo. Saudi Journal of Biological Sciences. 2009. Vol. 16, no. 2, pp.85-94.
https://search.emarefa.net/detail/BIM-359025
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 93-94
Record ID
BIM-359025