Effect of azadirachtin of neemix-4.5 on SWR J mice

Joint Authors

Husayn, H. I.
Abu Tarbush, F. M.
al-Ashmawi, H. M.
al-Rajihi, D.
al-Assiry, M.

Source

Saudi Journal of Biological Sciences

Issue

Vol. 16, Issue 2 (31 Oct. 2009), pp.69-76, 8 p.

Publisher

Saudi Biological Society

Publication Date

2009-10-31

Country of Publication

Saudi Arabia

No. of Pages

8

Main Subjects

Veterinary Medicine

Topics

Abstract EN

Inbred normal SWR / J male and female mice, 8–10 weeks old and weighing 22.55–26.72 g, were used throughout the study.

A total of 100 males and 100 females were used and were divided into 20 groups, 10 animals in each group.

Azadirachtin of neemix-4.5, a commercial botanical pesticide derived from the neem tree, orally administered to male and female SWR / J mice at a dose level 9.0 mg / kg (1 / 10 LD50) for different treatment periods (2, 4, 6, 8 or 11.5 weeks) has produced signs of toxicity, mortality and changes in body and tissue weights of both sexes at almost all treated periods used in the present study.

Moreover the oral administration of this dose level for 11.5 weeks has also resulted in some histopathological changes in the livers, kidneys and testes of treated animals compared with the control group, and the degree of these changes ranged from mild to severe in these organs of treated males.

However, conflicting results have been reported concerning the toxicity of azadirachtin in mammalian species using different formulations of neem-based pesticides.

It appears, therefore, that the toxicity produced by neemix-4.5 in the present study may be due to factors other than azadirachtin in this formulation.

American Psychological Association (APA)

Abu Tarbush, F. M.& al-Ashmawi, H. M.& Husayn, H. I.& al-Rajihi, D.& al-Assiry, M.. 2009. Effect of azadirachtin of neemix-4.5 on SWR J mice. Saudi Journal of Biological Sciences،Vol. 16, no. 2, pp.69-76.
https://search.emarefa.net/detail/BIM-359111

Modern Language Association (MLA)

Abu Tarbush, F. M.…[et al.]. Effect of azadirachtin of neemix-4.5 on SWR J mice. Saudi Journal of Biological Sciences Vol. 16, no. 2 (Oct. 2009), pp.69-76.
https://search.emarefa.net/detail/BIM-359111

American Medical Association (AMA)

Abu Tarbush, F. M.& al-Ashmawi, H. M.& Husayn, H. I.& al-Rajihi, D.& al-Assiry, M.. Effect of azadirachtin of neemix-4.5 on SWR J mice. Saudi Journal of Biological Sciences. 2009. Vol. 16, no. 2, pp.69-76.
https://search.emarefa.net/detail/BIM-359111

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 75-76

Record ID

BIM-359111