Effect of gold nanoparticles on glutathione and malondialdehyde levels in liver, lung and heart of rats
Joint Authors
Abd al-Halim, Muhammad Anwar K.
Khan, Hasib Ahmad
al-Ayid, Muhammad S.
al-Ḥumidi, Abd Allah S.
Source
Saudi Journal of Biological Sciences
Issue
Vol. 19, Issue 4 (31 Dec. 2012), pp.461-464, 4 p.
Publisher
Publication Date
2012-12-31
Country of Publication
Saudi Arabia
No. of Pages
4
Main Subjects
Topics
Abstract EN
We studied the effect of gold nanoparticles (NPs) on oxidative stress markers including reduced glutathione (GSH) and malondialdehyde (MDA) in different organs of rats.
Adult male Wistar-Kyoto rats were randomly divided into 3 groups of 5 animals each.
One group served as control and received vehicle only.
The remaining two groups were treated with 50 ll of 10 nm sized gold NPs, daily for 3 and 7 days, respectively.
The rats were sacrificed 24 h after the last injection of NPs.
Administration of gold NPs did not cause any significant change in GSH levels in liver, lung and heart on day 3 or day 7.
There was no significant effect of gold NPs on MDA levels in lung and heart whereas significant increases in MDA levels were found in the liver of rats treated with gold nanoparticles on both 3 and 7 days post-dosing (ANOVA F =7.113, P = 0.010).
In conclusion, the findings of this preliminary study suggest that gold NPs of 10 nm diameter produce significant lipid peroxidation in rat liver however lungs and heart do not show any oxidative stress.
Further studies are warranted to examine the effects of a broader dose range of gold NPs on the levels of free radical indices in different organs of rats
American Psychological Association (APA)
Khan, Hasib Ahmad& Abd al-Halim, Muhammad Anwar K.& al-Ayid, Muhammad S.& al-Ḥumidi, Abd Allah S.. 2012. Effect of gold nanoparticles on glutathione and malondialdehyde levels in liver, lung and heart of rats. Saudi Journal of Biological Sciences،Vol. 19, no. 4, pp.461-464.
https://search.emarefa.net/detail/BIM-359337
Modern Language Association (MLA)
Khan, Hasib Ahmad…[et al.]. Effect of gold nanoparticles on glutathione and malondialdehyde levels in liver, lung and heart of rats. Saudi Journal of Biological Sciences Vol. 19, no. 4 (2012), pp.461-464.
https://search.emarefa.net/detail/BIM-359337
American Medical Association (AMA)
Khan, Hasib Ahmad& Abd al-Halim, Muhammad Anwar K.& al-Ayid, Muhammad S.& al-Ḥumidi, Abd Allah S.. Effect of gold nanoparticles on glutathione and malondialdehyde levels in liver, lung and heart of rats. Saudi Journal of Biological Sciences. 2012. Vol. 19, no. 4, pp.461-464.
https://search.emarefa.net/detail/BIM-359337
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 464
Record ID
BIM-359337