Biochemical and histological impact of vernonia amygdalina supplemented diet in obese rats
Joint Authors
Atangwho, Item J.
Edet, Emmanuel E.
Uti, Daniel E.
Obi, Augustine U.
Asmawi, Muhd. Z.
Ahmad, Maryam
Source
Saudi Journal of Biological Sciences
Issue
Vol. 19, Issue 3 (30 Sep. 2012), pp.385-392, 8 p.
Publisher
Publication Date
2012-09-30
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Topics
Abstract EN
This study was carried out to evaluate the anti-obesity effect of Vernonia amygdalina Del.
(VA) supplemented diet.
VA leaf powder was fed at 5% and 15% to diet-induced obese rats for 4 weeks and its effect compared with orlistat (5.14 mg/kg p.o.), an anti-obesity drug.
Food intake, body and organ weights, total body fat, some lipid components and amino transaminase activities in serum, hepatocytes and brain; as well as serum glucose, were measured during or at end of the study.
Result showed respective decrease of 12.78% and 38.51% in body weight gain, of VA fed rats against 17.45% of orlistat at end of study (P <0.05); but with no effect on food intake.
Total body fat was lowered by 28.04% and 30.02% vs.
obese control rats (CDC) (P < 0.05).
Furthermore, serum triacylglycerol (TG), serum and brain total cholesterol (TCHOL), were down regulated at 15% VA supplementation (P < 0.05).
Serum glucose which increased in obese rats by 46.26% (P <0.05) vs.
NC, indicating intolerance, was restored by VA (38.75% and 34.65%) and orlistat (31.80%) vs.
CDC (P < 0.05).
VA diet also exerted hepato-protection, via lowering serum alanine
American Psychological Association (APA)
Atangwho, Item J.& Edet, Emmanuel E.& Uti, Daniel E.& Obi, Augustine U.& Asmawi, Muhd. Z.& Ahmad, Maryam. 2012. Biochemical and histological impact of vernonia amygdalina supplemented diet in obese rats. Saudi Journal of Biological Sciences،Vol. 19, no. 3, pp.385-392.
https://search.emarefa.net/detail/BIM-359442
Modern Language Association (MLA)
Atangwho, Item J.…[et al.]. Biochemical and histological impact of vernonia amygdalina supplemented diet in obese rats. Saudi Journal of Biological Sciences Vol. 19, no. 3 (2012), pp.385-392.
https://search.emarefa.net/detail/BIM-359442
American Medical Association (AMA)
Atangwho, Item J.& Edet, Emmanuel E.& Uti, Daniel E.& Obi, Augustine U.& Asmawi, Muhd. Z.& Ahmad, Maryam. Biochemical and histological impact of vernonia amygdalina supplemented diet in obese rats. Saudi Journal of Biological Sciences. 2012. Vol. 19, no. 3, pp.385-392.
https://search.emarefa.net/detail/BIM-359442
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 392
Record ID
BIM-359442