![](/images/graphics-bg.png)
Association between the polymorphisms of matrix metalloproteinases 9 and 3 genes and risk of myocardial infarction in Egyptian patients
Joint Authors
Wilson, Manal M.
Suwaylim, Nadiyah I.
Radwan, Iman R.
Andraos, Ashraf W.
Ibrahim, Bahir E.
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 14, Issue 2 (30 Apr. 2013), pp.143-148, 6 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2013-04-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Topics
Abstract EN
The present study investigated the relationship between the genetic polymorphisms in MMP-9 and MMP-3 genes and acute myocardial infarction (AMI).
We examined 40 patients with acute myocardial infarction and 40 age and sex matched controls for MMP-9 functional promoter polymorphism ( 1562 C > T) and MMP-3 (5A / 6A) deletion / insertion polymorphism using restriction fragment length polymorphism (RFLP) for amplified genomic DNA.
The frequencies of the combined mutant genotypes CT and TT in the ( 1562 C > T) MMP9 were significantly higher in AMI patients (20 %) when compared to the controls (0 %) (p value = 0.005) showing an association between these genotypes and AMI.
Also there was a significant difference between 5A / 5A genotype and 5A allele frequencies when both are compared in the patients (25 % and 35 %) and the controls (2.5 % and 18.75 %) (p = 0.009 ; OR = 13 ; CI = 1.576–107.233) ; and (p = 0.02 ; OR = 2.333, CI = 1.130–4.820) respectively.
In conclusion, the 1562C > T polymorphism of the MMP9 gene is strongly associated with acute myocardial infarction in the Egyptian population.
Furthermore, our study supported the presence of the 5A / 5A genotype of MMP3 gene promoter polymorphism as a risk factor of AMI in Egyptian patients.
Meanwhile, the race selection should be paid more attention since the pathogenesis of a disease might have different bases in different racial population groups.
American Psychological Association (APA)
Suwaylim, Nadiyah I.& Radwan, Iman R.& Andraos, Ashraf W.& Ibrahim, Bahir E.& Wilson, Manal M.. 2013. Association between the polymorphisms of matrix metalloproteinases 9 and 3 genes and risk of myocardial infarction in Egyptian patients. The Egyptian Journal of Medical Human Genetics،Vol. 14, no. 2, pp.143-148.
https://search.emarefa.net/detail/BIM-359665
Modern Language Association (MLA)
Suwaylim, Nadiyah I.…[et al.]. Association between the polymorphisms of matrix metalloproteinases 9 and 3 genes and risk of myocardial infarction in Egyptian patients. The Egyptian Journal of Medical Human Genetics Vol. 14, no. 2 (Apr. 2013), pp.143-148.
https://search.emarefa.net/detail/BIM-359665
American Medical Association (AMA)
Suwaylim, Nadiyah I.& Radwan, Iman R.& Andraos, Ashraf W.& Ibrahim, Bahir E.& Wilson, Manal M.. Association between the polymorphisms of matrix metalloproteinases 9 and 3 genes and risk of myocardial infarction in Egyptian patients. The Egyptian Journal of Medical Human Genetics. 2013. Vol. 14, no. 2, pp.143-148.
https://search.emarefa.net/detail/BIM-359665
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 148
Record ID
BIM-359665