Association between the polymorphisms of matrix metalloproteinases 9 and 3 genes and risk of myocardial infarction in Egyptian patients

Abstract EN

The present study investigated the relationship between the genetic polymorphisms in MMP-9 and MMP-3 genes and acute myocardial infarction (AMI).

We examined 40 patients with acute myocardial infarction and 40 age and sex matched controls for MMP-9 functional promoter polymorphism ( 1562 C > T) and MMP-3 (5A / 6A) deletion / insertion polymorphism using restriction fragment length polymorphism (RFLP) for amplified genomic DNA.

The frequencies of the combined mutant genotypes CT and TT in the ( 1562 C > T) MMP9 were significantly higher in AMI patients (20 %) when compared to the controls (0 %) (p value = 0.005) showing an association between these genotypes and AMI.

Also there was a significant difference between 5A / 5A genotype and 5A allele frequencies when both are compared in the patients (25 % and 35 %) and the controls (2.5 % and 18.75 %) (p = 0.009 ; OR = 13 ; CI = 1.576–107.233) ; and (p = 0.02 ; OR = 2.333, CI = 1.130–4.820) respectively.

In conclusion, the 1562C > T polymorphism of the MMP9 gene is strongly associated with acute myocardial infarction in the Egyptian population.

Furthermore, our study supported the presence of the 5A / 5A genotype of MMP3 gene promoter polymorphism as a risk factor of AMI in Egyptian patients.

Meanwhile, the race selection should be paid more attention since the pathogenesis of a disease might have different bases in different racial population groups.