Blood chemical changes and renal histological alterations induced by gentamicin in rats
Joint Authors
Mubarak, Muhammad
al-Urayfi, Suud
al-Duaiss, Amin
al-Farraj, S. A.
al-Isa, Muhammad Sad
al-Dahmash, B.
al-Yahya, Hamad
al-Qahtani, Sad
Source
Saudi Journal of Biological Sciences
Issue
Vol. 19, Issue 1 (31 Mar. 2012), pp.103-110, 8 p.
Publisher
Publication Date
2012-03-31
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Topics
Abstract EN
Gentamicin is an effective widely used antibiotic, but the risk of nephrotoxicity and oxidative damage limit its long-term use.
Hence, the current study aims to elucidate such hazardous effects.
To achieve the study aim male Wistar albino rats (Rattus norvegicus) were exposed to gentamicin to investigate the resultant blood chemical changes and renal histological alterations.
In comparison with control rats, gentamicin produced outstanding tubular, glomerular and interstitial alterations that included degeneration, necrosis, cytolysis and cortical tubular desquamation together with mesangial hypercellularity, endothelial cell proliferation and blood capillary congestion.
Compared with control animals significant blood chemical changes (P <0.05) including free radicals, ALT, AST, ALP, serum creatinine and serum urea were recorded in gentamicin-injected animals.
The findings revealed that exposure to gentamicin can induce significant histological alterations in the kidney as well as remarkable blood chemical changes that might indicate marked renal failure.
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American Psychological Association (APA)
al-Urayfi, Suud& al-Duaiss, Amin& al-Qahtani, Sad& al-Farraj, S. A.& al-Isa, Muhammad Sad& al-Dahmash, B.…[et al.]. 2012. Blood chemical changes and renal histological alterations induced by gentamicin in rats. Saudi Journal of Biological Sciences،Vol. 19, no. 1, pp.103-110.
https://search.emarefa.net/detail/BIM-360063
Modern Language Association (MLA)
al-Urayfi, Suud…[et al.]. Blood chemical changes and renal histological alterations induced by gentamicin in rats. Saudi Journal of Biological Sciences Vol. 19, no. 1 (2012), pp.103-110.
https://search.emarefa.net/detail/BIM-360063
American Medical Association (AMA)
al-Urayfi, Suud& al-Duaiss, Amin& al-Qahtani, Sad& al-Farraj, S. A.& al-Isa, Muhammad Sad& al-Dahmash, B.…[et al.]. Blood chemical changes and renal histological alterations induced by gentamicin in rats. Saudi Journal of Biological Sciences. 2012. Vol. 19, no. 1, pp.103-110.
https://search.emarefa.net/detail/BIM-360063
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 109-110
Record ID
BIM-360063