Raised plasma homocysteine as a risk factor for idiopathic and recurrent deep-vein thrombosis
Other Title(s)
زيادة مستوى الهوموسستيين بالبلازما كعامل خطورة مؤثر في حالات الجلطة الوريدية العميقة الأولية و المتكررة
Joint Authors
Kamil, Nifin Abd al-Munim Hasan
Mubarak, Muhammad Ala al-Din
Ahmad, Suhayr Muhammad
Sakla, Mariana Atif Ata Allah
Source
Issue
Vol. 30, Issue 3 (30 Sep. 2006), pp.149-156, 8 p.
Publisher
Assiut University Faculty of Medicine
Publication Date
2006-09-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Previous studies have suggested that hyperhomocysteinemia (Hyper-Hcy) may be a risk factor for venous thrombosis.
To assess the risk of venous thrombosis associated with Hyper-Hcy, we studied plasma total homocysteine (tHcy) levels in patients with deep venous thrombosis and in normal control subjects- Methods.
Fasting tHcy levels were measured in 40 consecutive patients with objectively diagnosed deep venous thrombosis and in 20 healthy controls matched to the patients according to age and sex.
Hyper-Hcy was defined as plasma total homocysteine level >15 jimol/l.
Results.
Plasma homocysteine level was significantly higher in patients than in controls.
It was significantly higher in patients with idiopathic (unprovoked) vein thrombosis than in patients with secondary disease (associated with at least one predisposing factor).
Mean homocysteine was higher in male than in female patients and increased with age.
Hyperhomocysteinemia was more frequent in patients with relapsing disease than in those presenting with a single episode.
Mean homocysteine level was similar in patients presenting with either proximal or calf vein thrombosis.
Conclusion.
Mild Hyper-Hcy is an independent risk factor for deep- vein thrombosis, more prevalent in patients with idiopathic or recurrent disease.
The next question to be answered is whether homocysteine-lowering therapy - folic acid, vitamin B6 or vitamin B12 -contributes to the prevention of recurrent venous thrombosis.
Key words: Homocysteine- Hyperhomocysteinemia- Deep venous thrombosis.
American Psychological Association (APA)
Mubarak, Muhammad Ala al-Din& Kamil, Nifin Abd al-Munim Hasan& Ahmad, Suhayr Muhammad& Sakla, Mariana Atif Ata Allah. 2006. Raised plasma homocysteine as a risk factor for idiopathic and recurrent deep-vein thrombosis. Assiut Medical Journal،Vol. 30, no. 3, pp.149-156.
https://search.emarefa.net/detail/BIM-36020
Modern Language Association (MLA)
Mubarak, Muhammad Ala al-Din…[et al.]. Raised plasma homocysteine as a risk factor for idiopathic and recurrent deep-vein thrombosis. Assiut Medical Journal Vol. 30, no. 3 (Sep. 2006), pp.149-156.
https://search.emarefa.net/detail/BIM-36020
American Medical Association (AMA)
Mubarak, Muhammad Ala al-Din& Kamil, Nifin Abd al-Munim Hasan& Ahmad, Suhayr Muhammad& Sakla, Mariana Atif Ata Allah. Raised plasma homocysteine as a risk factor for idiopathic and recurrent deep-vein thrombosis. Assiut Medical Journal. 2006. Vol. 30, no. 3, pp.149-156.
https://search.emarefa.net/detail/BIM-36020
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 155-156
Record ID
BIM-36020