Paracetamol, ondansetron, granisetron, magnesium sulfate and lidocaine and reduced propofol injection pain
Joint Authors
Alipour, Muhammad
Tabari, Masoomeh
Alipour, Masoomeh
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 16, Issue 3 (31 Mar. 2014), pp.1-5, 5 p.
Publisher
Publication Date
2014-03-31
Country of Publication
United Arab Emirates
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background: Propofol is a most widely used intravenous anesthetic drug.
One of its most common complications is the pain upon injection; therefore, different methods, with various effects, have been proposed in order to alleviate the pain.
Objectives: This study investigates the effects of paracetamol, ondansetron, granisetron, magnesium sulfate and lidocaine drugs on reducing the pain of propofol injection during anesthetic induction.
Also, the hemodynamic changes will be analyzed.
Patients and Methods: This is an interventional study containing 336 patients underwent elective orthopedic surgeries in Educational Hospitals of Mashhad University, using systematic sampling, the patients were divided into six groups.
A 20-gauge needle was inserted into a venous vessel in the back of the hand and 100 cc of Ringer serum was injected into the vein, which was applied proximal to the injection site.
Afterwards, paracetamol 2 mg/kg (group p), magnesium sulfate 2 mmol (group M), ondansetron 4 mg (group O), granisetron 2 mg (group G), lidocaine 40 mg (group L) and 5cc saline (group S) were injected into the vessel, after 60 seconds, the tourniquet was opened.
One quarter of the total dose of propofol (2.5 mg/kg) was injected with a flow rate of 4 mg/sec and then the injection pain was measured.
Finally, the fentanyl (2 μg/kg), atracurium 0.5 mg/kg, and the remaining dose of propofol were injected and the vital signs were recorded before the administration of propofol and 1, 3, 5 and 10 minutes after the propofol injection.
Results: The six groups did not significantly differ, regarding their gender, weight or age.
Propofol injection pain was less in L and G groups, in comparison with the others (P ≤ 0.001).
By analyzing the hemodynamic changes, it was observed that the least amount of change in mean arterial pressure was observed in the paracetamol group.
Conclusions: The reduction of propofol injection pain was observed by using medications (in comparison with normal saline), but it was more significant in groups G and L.
Moreover, Hypotension was higher in groups S and G and it was lessened in group P.
American Psychological Association (APA)
Alipour, Muhammad& Tabari, Masoomeh& Alipour, Masoomeh. 2014. Paracetamol, ondansetron, granisetron, magnesium sulfate and lidocaine and reduced propofol injection pain. Iranian Red Crescent Medical Journal،Vol. 16, no. 3, pp.1-5.
https://search.emarefa.net/detail/BIM-360597
Modern Language Association (MLA)
Alipour, Muhammad…[et al.]. Paracetamol, ondansetron, granisetron, magnesium sulfate and lidocaine and reduced propofol injection pain. Iranian Red Crescent Medical Journal Vol. 16, no. 3 (Mar. 2014), pp.1-5.
https://search.emarefa.net/detail/BIM-360597
American Medical Association (AMA)
Alipour, Muhammad& Tabari, Masoomeh& Alipour, Masoomeh. Paracetamol, ondansetron, granisetron, magnesium sulfate and lidocaine and reduced propofol injection pain. Iranian Red Crescent Medical Journal. 2014. Vol. 16, no. 3, pp.1-5.
https://search.emarefa.net/detail/BIM-360597
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 5
Record ID
BIM-360597