Resistance to ondansetron : role of pharmacogenetics in post-operative nausea and vomiting
Joint Authors
Farhat, Kulthum
Ali, Shabana
Pasha, Anwar Kamal
Ismail, Muhammad
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 14, Issue 4 (31 Oct. 2013), pp.331-336, 6 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2013-10-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Topics
Abstract EN
Post-operative nausea and vomiting is the most annoying and at the same time a dangerous side effect of general anaesthesia.
Ondansetron is a routinely used anti emetic drug which is being administered by the trial and error principle.
Though it did revolutionized the management of this condition but by and large failed to completely eliminate the problem.
Recently an important factor possibly elucidating this failure is said to be the differing expression of genes controlling proteins that are involved in transport and receptors related to this drug.
Quite surprisingly these transporter and receptor pathways have been found to be polymorphic and at the same time shown to be related to efficacy of the drug.
The differentiation between those responding to treatment and those not responding may pave a way to individualize treatment for emesis to a greater extent.
This review highlights the pharmacogenetics related to this commonly used anti-emetic drug in anaesthesia.
It is visualized as a promising way to achieve the target of individualized therapy.
It seems obvious that pharmacogenetics will become an important field of anaesthesia research in the future.
American Psychological Association (APA)
Farhat, Kulthum& Ismail, Muhammad& Ali, Shabana& Pasha, Anwar Kamal. 2013. Resistance to ondansetron : role of pharmacogenetics in post-operative nausea and vomiting. The Egyptian Journal of Medical Human Genetics،Vol. 14, no. 4, pp.331-336.
https://search.emarefa.net/detail/BIM-360612
Modern Language Association (MLA)
Ismail, Muhammad…[et al.]. Resistance to ondansetron : role of pharmacogenetics in post-operative nausea and vomiting. The Egyptian Journal of Medical Human Genetics Vol. 14, no. 4 (Oct. 2013), pp.331-336.
https://search.emarefa.net/detail/BIM-360612
American Medical Association (AMA)
Farhat, Kulthum& Ismail, Muhammad& Ali, Shabana& Pasha, Anwar Kamal. Resistance to ondansetron : role of pharmacogenetics in post-operative nausea and vomiting. The Egyptian Journal of Medical Human Genetics. 2013. Vol. 14, no. 4, pp.331-336.
https://search.emarefa.net/detail/BIM-360612
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 335-336
Record ID
BIM-360612