Insight into Nek2A activity regulation and its pharmacological prospects
Joint Authors
Kumar, Ambuj
Purohit, Rituraj
Rajendran, Vidya
Sethumadhavan, Rao
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 14, Issue 3 (31 Jul. 2013), pp.213-219, 7 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2013-07-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Nek2A is an essential component of cell cycle progression.
It regulates the reorganization of the microtubule network at the G2 / M transition and controls the centriole–centriole linkage of the cells entering mitosis.
The overexpression of Nek2A coding gene has been widely reported in several cancer-associated disorders.
In order to design a potent inhibitor and to control its expression mechanism, it is important to understand the structural orientation and the underlying molecular mechanisms associated with its activity regulation.
In this study we have summarized the important information that will help in understanding the functional and activity regulation of Nek2A splice variants, which will further facilitate in designing a potent inhibitor against the cancer associated cases.
We have also presented previously reported studies on the domain specifications and inhibitor biosynthesis that provide an insight into its specific target residue regions for developing active and more potent inhibitors.
American Psychological Association (APA)
Kumar, Ambuj& Rajendran, Vidya& Sethumadhavan, Rao& Purohit, Rituraj. 2013. Insight into Nek2A activity regulation and its pharmacological prospects. The Egyptian Journal of Medical Human Genetics،Vol. 14, no. 3, pp.213-219.
https://search.emarefa.net/detail/BIM-360709
Modern Language Association (MLA)
Kumar, Ambuj…[et al.]. Insight into Nek2A activity regulation and its pharmacological prospects. The Egyptian Journal of Medical Human Genetics Vol. 14, no. 3 (Jul. 2013), pp.213-219.
https://search.emarefa.net/detail/BIM-360709
American Medical Association (AMA)
Kumar, Ambuj& Rajendran, Vidya& Sethumadhavan, Rao& Purohit, Rituraj. Insight into Nek2A activity regulation and its pharmacological prospects. The Egyptian Journal of Medical Human Genetics. 2013. Vol. 14, no. 3, pp.213-219.
https://search.emarefa.net/detail/BIM-360709
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 217-219
Record ID
BIM-360709