The effect of atenolol and combination of atenolol and thiazide diuretic on the lipid profile in hypertensive patients

Abstract EN

Objectives : To assess the effect of atenolol and combination of atenolol and diuresam® (hydrochlorthiazide, ٢٥ mg and amiloride, ٥ mg) on the lipid profile including serum total cholesterol, triglyceride, very low density lipoprotein-cholesterol (VLDL-C), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein-cholesterol (HDL C) in hypertensive patients.

Design : Case-control study.

Setting : The study was conducted in Outpatient department of Ibn-Senna Hospital in Mosul, during the period from December ٢٠٠٣ to July ٢٠٠٤.

Participants : Fifty hypertensive patients under atenolol therapy (١٠٠ mg / day) and ٤٠ hypertensive patients under combination therapy of atenolol (١٠٠ mg / day) and diuresam® (one tablet every other day).

In addition to that, ٥٠ stage ١ hypertensive patients without treatment served as a control group.

Mean outcome measures : lipid profile in the treated hypertensive patients were compared with those measurements in the control group by using Duncan test.

Results : In the hypertensive patients treated with atenolol, serum total cholesterol, triglyceride, VLDL-C and LDL-C were significantly higher (P < ٠.٠٥) than those values in the control group, at the same time HDL-C did not change.

The measurements of the lipid profile of the atenolol group were not significantly different from those measurements in the combination treated group of atenolol and diuresam®.

Conclusion : Chronic use of atenolol or combination of atenolol and diuresam® is associated with a significant increase in serum lipid profile.

However, diuresam® in moderate dose might not increase serum lipid profile.