Evaluating kidney damage from vesico-ureteral reflux in children
Joint Authors
Brugnara M.
Zeffianello M.
Franchini M.
Fanos V.
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 20, Issue 1 (28 Feb. 2009), pp.57-68, 12 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2009-02-28
Country of Publication
Saudi Arabia
No. of Pages
12
Main Subjects
Topics
Abstract EN
To review the most relevant clinical studies that evaluate kidney damage in children with primary vesico-ureteral reflux (VUR), we reviewed and compared randomized controlled trials and clinical trials from scientific literature.
In these studies, vesico-ureteral reflux was diagnosed by voiding cystourethrogram and kidney damage was assessed by either DMSA scan or urography.
Relative risk with 95% confidence intervals was calculated using Review Manager Software (The Cochrane Collaboration, 2000).
The overall relative risk of kidney damage shown by DMSA scan and urography was statistically higher in children with vesico-ureteral reflux of various degrees than in controls (3.7 times and 2.8 times, respectively).
However, in high-grade VUR, the relative risk of congenital kidney damage was 5.6 times that of controls.
We conclude that severe VUR is frequently associated with early kidney damage, perhaps with prenatal onset.
Progression of kidney damage may depend on the severity of VUR and untreated urinary tract infections.
Prevention of congenital kidney damage from severe VUR is possible when there is early intervention, even during fetal growth.
American Psychological Association (APA)
Zeffianello M.& Franchini M.& Brugnara M.& Fanos V.. 2009. Evaluating kidney damage from vesico-ureteral reflux in children. Saudi Journal of Kidney Diseases and Transplantation،Vol. 20, no. 1, pp.57-68.
https://search.emarefa.net/detail/BIM-36141
Modern Language Association (MLA)
Zeffianello M.…[et al.]. Evaluating kidney damage from vesico-ureteral reflux in children. Saudi Journal of Kidney Diseases and Transplantation Vol. 20, no. 1 (Jan. 2009), pp.57-68.
https://search.emarefa.net/detail/BIM-36141
American Medical Association (AMA)
Zeffianello M.& Franchini M.& Brugnara M.& Fanos V.. Evaluating kidney damage from vesico-ureteral reflux in children. Saudi Journal of Kidney Diseases and Transplantation. 2009. Vol. 20, no. 1, pp.57-68.
https://search.emarefa.net/detail/BIM-36141
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 66-68
Record ID
BIM-36141