Plasma fibrinogen and D-dimer in patients with acute myocardial infarction

Abstract EN

Objectives: To investigate the plasma fibrinogen level and D-dimer reaction in patients with acute myocardial infarction (AMI) together with other haematological parameters.

Design: A prospective clinico-haematological study.

Setting: Intensive coronary care unit in Ibn-Sina teaching hospital in Mosul during a period of 4 months from October 2004.

Participants: Forty patients with acute myocardial infarction together with a control group of 40 subjects.

Main outcome measures: Basic haematological parameters, plasma fibinogen level and plasma D-dimer reaction tests.

Biochemical tests including cardiac enzymes measurement as creatine kinase (CK) and asparate transaminase (AST) were performed.

Results: Plasma fibrinogen level, white blood cell count and neutrophils count were significantly higher in patients compared to control group with P values (<0.05) (<0.01) and (<0.05) respectively.

Positive plasma D-dimer reaction was significantly more frequent in patients than in control group (p<0.05).

High plasma fibrinogen level and positive plasma D-dimer reaction were seen in those with worse outcome with p-value (<0.05), (<0.05) respectively.

Plasma fibrinogen was significantly higher in those with extensive infarction compared to others (p<0.05).

Conclusion: High plasma fibrinogen and positive plasma D-dimer reaction were more frequently seen in patients with complicated course of myocardial infarction.