Vitamin D2 as humoral immunosuppressenint rabbit

Abstract EN

Serial concentrations of vitamin D2 that ranges from 1.7-34 IU were made in 2% egg albumin aqious solution and used for rabbit priming through multisite and oral protocols.

Meantime, same vitamin D2 concentration incorporated in the diluting buffur of the hyperimmune and immunesera of anti EA specificity and titred against egg albumin coated erythrocytes.

The immunomodulation effect was scored as either titre enhancement or titer reduction .vit.

D2 was found as being humoral immunosuppressant and of dose dependent type .

The dose response relationship was of simple linear type .

Such suppression effect was evident both invivo during the immune response time curve and invitro on ready made anti EA antibody titers .The humoral immunotoxicity parameters as NOL threshold and activity range were determined vit.

D2 can be of help in maintenance and treatment of autoimmune disease and graft incompatibility conditions.