Immunology of E. coli persistant pyuria

Abstract EN

Fourty Persistent Pyuria Patients were diagnosed as E.

coli persistant pyuria .

Of which 33 were Immune (In a sense of mounting normal adapted immune response) and seven were immunocompromised (In a sense of mounting subnormal adapted immune response .The female / Male ratio was 13/27 .

The patients age range was 30-70 years .The median total serum protein was 7.274 g/dl .

Likewise the median serum total globulin was 4.302 g/dl .

while the median of systemic to the median of mucosal globulin ratio was 0.69 .

These scores were generally higher than those of normal control subjects .

The median immunoglobulin class concentrations were 2.339, 0.195 and 0.309 g/dl to classes IgG , IgM and IgA respectively .

E.

coli immunodominant epitopes were intiating specific circulating and mucosal agglutinin as well as significant leucocytes inhibition factors in immune patients and nonsignificant in immunocompromized .

Thus, E.

coli epitopes could be of T dependent type and activate either or both Th1 and Th2 lymphocyte, or it might be of T independent epitope type