Tumor suppressor gene (E-cadherin)and its role in normal and malignant cells
Author
Source
Issue
Vol. 1, Issue 3-4 (31 Dec. 2004)13 p.
Publisher
University of Babylon College of Medicine
Publication Date
2004-12-31
Country of Publication
Iraq
No. of Pages
13
Main Subjects
Abstract EN
Tumor suppressor genes (E-cadherin) are particularly active area of research in development and tumorigenesis.
The calcium-dependent interactions among E-cadherin molecules are critical for the formation and maintenance of adherent junctions in areas of epithelial cell-cell contact.
Loss of E-cadherin-mediated-adhesion characterises the transition from benign lesions to invasive, metastatic cancer.
Nevertheless, there is evidence that E-cadherins may also play a role in the wnt signal transduction pathway, together with other key molecules involved in it, such as beta-catenins and adenomatous poliposis coli gene products.
The structure and function of E-cadherin, gene and protein, in normal as well as in tumor cells are reviewed in this paper.
American Psychological Association (APA)
al-Tamimi, Ali Hasan. 2004. Tumor suppressor gene (E-cadherin)and its role in normal and malignant cells. Medical Journal of Babylon،Vol. 1, no. 3-4.
https://search.emarefa.net/detail/BIM-362051
Modern Language Association (MLA)
al-Tamimi, Ali Hasan. Tumor suppressor gene (E-cadherin)and its role in normal and malignant cells. Medical Journal of Babylon Vol. 1, no. 4-3 (2004).
https://search.emarefa.net/detail/BIM-362051
American Medical Association (AMA)
al-Tamimi, Ali Hasan. Tumor suppressor gene (E-cadherin)and its role in normal and malignant cells. Medical Journal of Babylon. 2004. Vol. 1, no. 3-4.
https://search.emarefa.net/detail/BIM-362051
Data Type
Journal Articles
Language
English
Notes
Includes appendices.
Record ID
BIM-362051