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Serum lipids in patients with active rheumatoid arthritis and it's relation to drug therapy
Joint Authors
Abd al-Samad, Talal
al-Zaydi, Ghazi T.
Source
Journal of the Faculty of Medicine Baghdad
Issue
Vol. 47, Issue 1 (31 Mar. 2005)5 p.
Publisher
University of Baghdad Faculty of Medicine
Publication Date
2005-03-31
Country of Publication
Iraq
No. of Pages
5
Main Subjects
Abstract EN
Objective To detect the changes in serum Lipids among Iraqi patients with active Rheumatoid Arthritis (RA) and the effects of drug therapy.
Patients and methods Fifty Iraqi patients with untreated active Rheumatoid Arthritis and 50 matched healthy control were studied with concentration on estimation of fasting serum Lipid profile which is repeated after 3month treatment with different disease modifying anti Rheumatic drugs (DMARDs) regimens.
Results Fifty Iraqi patients were included in this prospective study 47 females (94%) and 3 males (6%).
The mean age of patients was (45±3.20).
fifty healthy individuals were included in this study as a control group 45 females (90%) and 5 males (10%) the mean age of the control group was (44.9±2.9).
Our results showed a significant reduction of VLDL, LDL, HDL, serum cholesterol and serum triglyceride in-patients with active RA (p=<0.05, 0.001.
0.001, 0.001 and 0.018 respectively).
There was a significant relationship found between ESR and VLDL (P<0.05), serum triglyceride (P<0.04) and serum cholesterol (P<0.01).
And there was a significant relationship between serum lipids and articular index VLDL (P<0.05), serum cholesterol (P<0.01) and TG (P=0.01).
After 3-months treatment with Methotrexate or Methotrexate + Chloroquine ± large dose steroid or Chloroquine alone.
There was a significant reduction of inflammatory activity and serum lipids return to levels similar to that of control group.
Conclusions: The dyslipidemia associated with active RA characterized by low serum lipids and can be normalized by controlling disease activity with antirheumatic drugs including steroids.
American Psychological Association (APA)
Abd al-Samad, Talal& al-Zaydi, Ghazi T.. 2005. Serum lipids in patients with active rheumatoid arthritis and it's relation to drug therapy. Journal of the Faculty of Medicine Baghdad،Vol. 47, no. 1.
https://search.emarefa.net/detail/BIM-362487
Modern Language Association (MLA)
Abd al-Samad, Talal& al-Zaydi, Ghazi T.. Serum lipids in patients with active rheumatoid arthritis and it's relation to drug therapy. Journal of the Faculty of Medicine Baghdad Vol. 47, no. 1 (2005).
https://search.emarefa.net/detail/BIM-362487
American Medical Association (AMA)
Abd al-Samad, Talal& al-Zaydi, Ghazi T.. Serum lipids in patients with active rheumatoid arthritis and it's relation to drug therapy. Journal of the Faculty of Medicine Baghdad. 2005. Vol. 47, no. 1.
https://search.emarefa.net/detail/BIM-362487
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references.
Record ID
BIM-362487