Synthesis and antimicrobial activities of some octahydroxanthen-1, 8 dione derivatives

Abstract EN

Nine octahydroxanthen-1,8-dione derivatives together with their corresponding bisdimedone intermediates were designed and synthesized.

The total synthesis was designed from the appropriate disconnections of the target molecules.

An aldehyde was first condensed with dimedone to form the bisdimedone derivative, which was then cyclized to form the 9-substituted-1,8-diketo octahydro xanthenes.

The structures of the intermediates and the final products were confirmed by UV, IR, 1H and 13C-NMR studies.

The corresponding hydrazones and oximes were prepared.

Possible mechanistic explanation of the different synthetic routes together with their retrosynthetic analysis were dealt with.

The intermediates and the final products were scanned for their antibacterial activity against S.

aureus, E.

coli and P.

aeruginosa.

The compounds were found to possess some antimicrobial activity.

The com-pounds were assayed for their antifungal activity against C.

albicans.