An update on sickle cell nephropathy
Author
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 25, Issue 2 (30 Apr. 2014), pp.249-265, 17 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2014-04-30
Country of Publication
Saudi Arabia
No. of Pages
17
Main Subjects
Topics
Abstract EN
Sickle cell disease (SCD) is a major health problem in many countries.
Sickle cell nephropathy (SCN) is now a well-characterized entity with specific manifestations, risk factors and prognosis.
The presence of sickled erythrocytes in the renal medullary vessels is the hallmark of the disease with a variety of renal complications.
Renal manifestations of SCD include renal ischemia, microinfarcts, renal papillary necrosis and renal tubular abnormalities with variable clinical presentations.
Proximal tubule dysfunction generally impairs urinary concentration, while more distal tubule dysfunction may impair potassium excretion, leading to hyperkalemia.
Glomerular disease with proteinuria may develop due to ischemia and results in a compensatory increase in the renal blood flow and glomerular filtration rate; such hyperfiltration, combined with glomerular hypertrophy, probably contributes to glomerulosclerosis.
Acute and chronic kidney disease are the expected outcomes of the disease.
Both dialysis and kidney transplantation are effective renal replacement therapies for end-stage renal disease due to SCN, with a higher advantage for transplantation.
Whether bone marrow transplantation in the early stage of the disease can halt the progression of SCN is unknown and awaits clinical studies.
American Psychological Association (APA)
al-Hwish, Abd Allah. 2014. An update on sickle cell nephropathy. Saudi Journal of Kidney Diseases and Transplantation،Vol. 25, no. 2, pp.249-265.
https://search.emarefa.net/detail/BIM-363033
Modern Language Association (MLA)
al-Hwish, Abd Allah. An update on sickle cell nephropathy. Saudi Journal of Kidney Diseases and Transplantation Vol. 25, no. 2 (Apr. 2014), pp.249-265.
https://search.emarefa.net/detail/BIM-363033
American Medical Association (AMA)
al-Hwish, Abd Allah. An update on sickle cell nephropathy. Saudi Journal of Kidney Diseases and Transplantation. 2014. Vol. 25, no. 2, pp.249-265.
https://search.emarefa.net/detail/BIM-363033
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 261-265
Record ID
BIM-363033