Synthesis of cyclopentane-1, 2-dione-derived mannich bases and their biological activity
Dissertant
Thesis advisor
Muhammad, Muhammad Abd al-Karim
University
Omdurman Islamic University
Faculty
Faculty of Pharmacy
University Country
Sudan
Degree
Master
Degree Date
2011
English Abstract
Many Mannich bases were prepared from cyclopentene -1, 2-diones by using some secondary amines and aldehydes.They were synthesized by two different methods.
These bases were then condensed with ortho –phenylenediamine to afford the corresponding exchange products.
The corresponding reaction with 2, 3-diaminopyrridine so far failed The structure of intermediate and final products were elucidated by various spectroscopic methods (UV, IR and NMR spectroscopy) and some of the products were screened for antibacterial activity against two standared Gram-positive bacteria (Bacillus subtilis and Stophylococcus aureus), two Gram –negative bacteria (Escherichia coli and Pseudomonas aeroginosa) and two fungi (Aspergillus niger and Candida albicans) using cup–plate agar diffusion method.
Amoxicillin and gentamicin were used as standard antibacterials.
Clotrimazole and nystatin were employed as standard antifungals.
Some of these compounds showed activity against test organisms
Main Subjects
Topics
No. of Pages
62
Table of Contents
Table of contents.
Abstract.
Chapter One : Introduction.
Chapter Two : Materials and methods.
Chapter Three : Results and discussion.
References.
American Psychological Association (APA)
Khujali, Wiam Muhammad Ali. (2011). Synthesis of cyclopentane-1, 2-dione-derived mannich bases and their biological activity. (Master's theses Theses and Dissertations Master). Omdurman Islamic University, Sudan
https://search.emarefa.net/detail/BIM-363128
Modern Language Association (MLA)
Khujali, Wiam Muhammad Ali. Synthesis of cyclopentane-1, 2-dione-derived mannich bases and their biological activity. (Master's theses Theses and Dissertations Master). Omdurman Islamic University. (2011).
https://search.emarefa.net/detail/BIM-363128
American Medical Association (AMA)
Khujali, Wiam Muhammad Ali. (2011). Synthesis of cyclopentane-1, 2-dione-derived mannich bases and their biological activity. (Master's theses Theses and Dissertations Master). Omdurman Islamic University, Sudan
https://search.emarefa.net/detail/BIM-363128
Language
English
Data Type
Arab Theses
Record ID
BIM-363128