Crescentic glomerulonephritis in non-asthmatic churg-strauss syndrome

Abstract EN

A 58-year-old male presented with sensory motor polyneuropathy and rapidly progressive renal failure.

Investigations revealed marked peripheral eosinophilia and elevated perinuclear antineutrophil cytoplasmic antibody titers.

Renal biopsy showed pauci-immune crescentic glomerulonephritis with interstitial eosinophil infiltrates.

He had no history of asthma.

Computed tomography of the chest and X-ray of the paranasal sinuses were normal.

On Day 1, the patient developed ileal perforation.

Resected ileal segments showed small vessel vasculitis with extravascular eosinophils.

A diagnosis of non-asthmatic variant of Churg–Strauss syndrome was made.

Renal recovery was achieved in 12 weeks with a combination therapy of corticosteroid and cyclophosphamide.

The patient has been relapse-free for 12 months on oral prednisolone therapy.