Severe rhabdomyolysis and acute renal secondry to use of simvastatin in undiagnosed hypothyroidism
Author
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 20, Issue 1 (28 Feb. 2009), pp.127-129, 3 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2009-02-28
Country of Publication
Saudi Arabia
No. of Pages
3
Main Subjects
Topics
- Thyroid gland
- Kidneys
- Diseases
- Hypothyroidism
- Chronic diseases
- Therapeutics
- Statins
- Complications(Medicine)
- Kidney failure
- Diagnosis
- Rhabdomyolysis
Abstract EN
A 52-year-old Indian woman with underlying diabetes mellitus and hyperlipidemia, presented with generalized musculoskeletal pain and oliguria for three days.
The patient was taking 80 mg of simvastatin initiated 20 days earlier after cardiac catheterization for an inferior myocardial infarction.
Laboratory investigations revealed the following serum levels : creatine kinase 81,620 U / L, aspartate aminotransferase 2497 U / L, alanine aminotransferase 1304 U/L, blood urea nitrogen 21.7 mmol / L, creatinine 447 µmol/L, Free T4 12.6 pmol / L, and thyroid stimulating hormone (TSH) 22.7 µIU / L.
Simvastatin was discontinued and the patient received forced alkaline diuresis.
Her hypo thyroidism was treated with thyroxin, which was continued upon discharge, and her renal function recovered within two months.
This case report discusses the incidence of rhabdomyolysis in a patient with primary hypothyroidism receiving large doses of simvastatin.
American Psychological Association (APA)
Qari, Fayizah A.. 2009. Severe rhabdomyolysis and acute renal secondry to use of simvastatin in undiagnosed hypothyroidism. Saudi Journal of Kidney Diseases and Transplantation،Vol. 20, no. 1, pp.127-129.
https://search.emarefa.net/detail/BIM-36342
Modern Language Association (MLA)
Qari, Fayizah A.. Severe rhabdomyolysis and acute renal secondry to use of simvastatin in undiagnosed hypothyroidism. Saudi Journal of Kidney Diseases and Transplantation Vol. 20, no. 1 (Jan. 2009), pp.127-129.
https://search.emarefa.net/detail/BIM-36342
American Medical Association (AMA)
Qari, Fayizah A.. Severe rhabdomyolysis and acute renal secondry to use of simvastatin in undiagnosed hypothyroidism. Saudi Journal of Kidney Diseases and Transplantation. 2009. Vol. 20, no. 1, pp.127-129.
https://search.emarefa.net/detail/BIM-36342
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 129
Record ID
BIM-36342