Serum cystatin C : a surrogate marker for the characteristics of peritoneal membrane in dialysis patients
Joint Authors
Numan, Tarif
Shah, Iqbal Hamid
al-Wakil, Jamal S.
Hammad, Durdana
Mimun, Nawaz A. H.
Chaudhary, Abd al-Rauf
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 20, Issue 2 (30 Apr. 2009), pp.227-231, 5 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2009-04-30
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Topics
- Patients
- Kidneys
- Proteins
- Diseases
- Penal functions
- Medical examinations
- Hemodialysis
- Cystatin C
- Diagnosis
- Peritoneal dialysis
Abstract EN
To evaluate whether cystatin C levels can be a surrogate marker of creatinine clearance and reflect the characteristics of peritoneal membrane in dialysis patients, we performed peritoneal equilibration tests (PET) in 18 anuric adult chronic peritoneal dialysis (PD) patients with a mean age of 39.7 ± 20 years.
All the samples were analyzed for urea, creatinine, and cystatin C.
Peritoneal transport, mass transfer, and peritoneal clearance of cystatin C were calculated.
Correlation and regression analysis was done using cystatin C as a dependent variable and age, sex, height, weight, body surface area, and creatinine as independent variables.
Cystatin C demonstrated a significant time dependent increase of dialysate concentration and decline in the serum concentrations during PET, and a strong correlation between serum creatinine and serum cystatin C concentrations(r : 0.62, p = 0.008).
The trans-peritoneal clearance (mL /min /1.73 m 2 ) of cystatin C was related to its serum concentration and was similar to creatinine in its pattern but of smaller magnitude.
Peritoneal mass transfer (mg/4hr per 1.73 m 2 ) for cystatin C serum creatinine was 1.68 ± 0.67 and 73.3 ± 29.8, respectively.
The dialysis / plasma D / P cystatin C concentration was > 0.1 at 4hrs of PET denoted high peritoneal transport, while the values of < 0.1 denoted low transport type.
We conclude that cystatin C follows the same pattern of peritoneal exchange as creatinine but the magnitude of transfer is many folds lower than creatinine.
At present clinical utility of cystatin C in the evaluation of solute clearance is probably limited due to the minute amounts transferred across the membrane and the high renal clearance in the presence of residual renal function.
American Psychological Association (APA)
al-Wakil, Jamal S.& Hammad, Durdana& Mimun, Nawaz A. H.& Numan, Tarif& Shah, Iqbal Hamid& Chaudhary, Abd al-Rauf. 2009. Serum cystatin C : a surrogate marker for the characteristics of peritoneal membrane in dialysis patients. Saudi Journal of Kidney Diseases and Transplantation،Vol. 20, no. 2, pp.227-231.
https://search.emarefa.net/detail/BIM-36385
Modern Language Association (MLA)
al-Wakil, Jamal S.…[et al.]. Serum cystatin C : a surrogate marker for the characteristics of peritoneal membrane in dialysis patients. Saudi Journal of Kidney Diseases and Transplantation Vol. 20, no. 2 (Mar. 2009), pp.227-231.
https://search.emarefa.net/detail/BIM-36385
American Medical Association (AMA)
al-Wakil, Jamal S.& Hammad, Durdana& Mimun, Nawaz A. H.& Numan, Tarif& Shah, Iqbal Hamid& Chaudhary, Abd al-Rauf. Serum cystatin C : a surrogate marker for the characteristics of peritoneal membrane in dialysis patients. Saudi Journal of Kidney Diseases and Transplantation. 2009. Vol. 20, no. 2, pp.227-231.
https://search.emarefa.net/detail/BIM-36385
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 231
Record ID
BIM-36385