Formulation and evalution of Commiphora Malmol gum resin extract tablets

Dissertant

Abd al-Latif, Azizah Dawud

Thesis advisor

Abd al-Karim, Abd al-Karim Muhammad

University

Omdurman Islamic University

Faculty

Faculty of Pharmacy

University Country

Sudan

Degree

Master

Degree Date

2012

English Abstract

The use of medicinal plants as raw material in the production of drugs is again gaining popularity. The aim of this study is to formulate a suitable dosage form from the crude extract of COMMIPHORA MYRRHA, which has many traditional uses and applications in different parts of the country. In this study, hot extraction by soxhelt method was selected from other different methods based on the biological, economical and pharmaceutical factors. Phytochemical screening test results of gum resin of COMMIPHORA MYRRHA to detect the major constituents showed the presence of flavonoids, tannins, saponin, Cyanogenic glycosides، Coumarins, Alkaloids and triterpens. These findings were confirmed by thin layer chromatography (TLC) results byusing threesolvent systems 1 (petrolum ether:alchol:ethanol as2:2 : 1), 2 (chloroform : petrolum ether as 4:1), 3 (tolouen : ethyl acetate). The selected extract showed a high antibacterial activity against standard bacterium Klebsiella pneumoniae, Sallmonilla, Protus, Staphylococcus aureus, Pseudomonas aeruginosa، Escrishia Coli (with concentration on Klebsiella pneumonia).

The standard Candida Albicans used would give high sensitivity with 30 % ethanolic extract and intermediate sensitivity with 70 % ethanolic extract Aspirgilous Niger while gave high sensitivity with 70 % ethanolic extract. In the process of formulating of low cost, safe, effective and reproducible dosage form, the wet granulation method was found to be the most suitable for the extract of the plant material due to bad compressibility and poor flowability.

After preformulation studies, the formula was prepared by using starch as a binder and primagel and Micro crystalline cellulose as disintegrant and filler respectivelly. The use of disintegrant in tablets, gave the disintegration time of 4 minutes Coloring agent was not needed, as the extract was mutually colored (acceptable brown color).

Also sweetening agent was not added as the taste was acceptable taste was. The quality control (QC) tests were carried out and good results were obtained .

QC test results complied with the requirements stated in official British and American pharmacopeias.

The carried out tests were: weight variation, friability, hardness, disintegration and dissolution test.

Main Subjects

Pharmacology

Topics

• Drugs

No. of Pages

71

Table of Contents

• APA
• MLA
• AMA

Language

English

Data Type

Arab Theses

Record ID

BIM-363908