The role of interleukine-6and interleukin -1 in failing heart

Abstract EN

Background : Interleukin (IL) 6 has attracted attention with regard to myocardial dysfunction because increased levels adequate correlate with the heart failure.

Heart failure is the inability of the heart to supply blood flow and therefore oxygen delivery to peripheral tissues and organs.

Under perfusion of organs leads to reduced exercise capacity, fatigue, and shortness of breath.

The cytokines like IL-1 may play a significant role in the pathogenesis of several forms of myocardial dysfunction.

Objective : To determine whether the increase level of interleukine-6 and interlukin-1 are important in prognosis of heart failure.

Method : The cytokine profile in patient group with heart failure (n = 80 mean ± 5.7) age (62.3 ± 5.7) years was compared with that of age matched healthy individuals (n = 20, mean ± SD) age of (59.7 ± 6.3) years.

Results : The results showed significant increased levels of interleukine-6 (IL-6) and interlukin-1 (IL-1) in patients with heart failure compared with those in the control group.

Conclusion : from this study we can conclude that the pro inflammatory interleukine-6 (IL-6) and interlukin-1 (IL-1) may provoke the condition of heart failure patients.