Vitamin e attenuates liver injury induced by exposure to lead, mercury, cadmium and copper in albino mice
Author
Source
Saudi Journal of Biological Sciences
Issue
Vol. 18, Issue 4 (31 Dec. 2011), pp.395-401, 7 p.
Publisher
Publication Date
2011-12-31
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
Abstract EN
Water pollution is the contamination of water resources by harmful wastes or toxins.
Both community and private sources of drinking water are susceptible to a myriad of chemical contaminants.
Heavy metals pollution of surface water can create health risks.
The present study was aimed to investigate the effect of vitamin E supplementation on male mice exposed to a mixture of some heavy metals (lead, mercury, cadmium and copper) in their drinking water for seven weeks.
Significant increases of blood alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma glutamyl transferase (GGT) were detected in heavy metals-treated mice.
Histopathologically, the liver sections from heavy metals-treated mice showed severe changes including disarrangement of hepatic strands, rupture in hepatocytes, advanced hepatocellular necrosis, dilation and congestion of blood vessels with hemorrhage, dense lymphocytic infiltration round the central vein and dark stained hepatocytic nuclei indicating cell pycnosis.
Administration of vitamin E at a dose of 50 IU / kg body weight, five times weekly improved the observed biochemical and histopathological changes induced by these heavy metals intoxication.
Hence, the results of this study suggest that vitamin E protects against these heavy metals-induced liver injury and the attenuating effect of vitamin E may be due to its antioxidant activity.
American Psychological Association (APA)
al-Attar, Atif M.. 2011. Vitamin e attenuates liver injury induced by exposure to lead, mercury, cadmium and copper in albino mice. Saudi Journal of Biological Sciences،Vol. 18, no. 4, pp.395-401.
https://search.emarefa.net/detail/BIM-364656
Modern Language Association (MLA)
al-Attar, Atif M.. Vitamin e attenuates liver injury induced by exposure to lead, mercury, cadmium and copper in albino mice. Saudi Journal of Biological Sciences Vol. 18, no. 4 (2011), pp.395-401.
https://search.emarefa.net/detail/BIM-364656
American Medical Association (AMA)
al-Attar, Atif M.. Vitamin e attenuates liver injury induced by exposure to lead, mercury, cadmium and copper in albino mice. Saudi Journal of Biological Sciences. 2011. Vol. 18, no. 4, pp.395-401.
https://search.emarefa.net/detail/BIM-364656
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 339-401
Record ID
BIM-364656