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Activity changes of molybdenum hydroxylases in liver, kidney and jejunum of streptozotocin-induced diabetic rats
Other Title(s)
تغيرات نشاطية إنزيمات الموليبيدنوم هيدروكسيلزز في كبد و كلية و صائم الجرذان المصابة بالسكري المستحث بالإستربتوزوتوسين
Author
al-Bar, Umar Abd al-Rahman Mustafa
Source
Journal of King Abdulaziz University : Sciences
Issue
Vol. 17, Issue 1 (31 Dec. 2005), pp.135-141, 7 p.
Publisher
King Abdulaziz University Scientific Publishing Center
Publication Date
2005-12-31
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
Abstract EN
The aim of this study is to investigate the effect of diabetes induction on the specific activity of two molybdenum hydroxylases, namely aldehyde oxidase and xanthine oxidase.
Streptozotocin in a single i.
p.
injection (65 mg / kg) induced diabetes in male Wistar rats as indicated by a sharp and significant increase of plasma glucose level after 5 days of the treatment.
Three tissues (liver, kidney and jejunum) were excised and assayed for the activity of aldehyde oxidase and xanthine oxidase.
Two substrates (phthalazine and 3-methylisoquinoline) were used to measure aldehyde oxidase activity, while xanthine was used for xanthine oxidase.
Hepatic aldehyde oxidase activity was increased significantly (P < 0.
025) in diabetic rats as compared to controls when phthalazine was used as a substrate.
The other two tissues (kidney, jejunum) did not show any significant variation in aldehyde oxidase activity when diabetic and control rats were compared.
No significant change of this enzymic activity was noted in the three tissues (liver, kidney and jejunum) when 3-methylisoquinoline was used as a substrate.
On the other hand, xanthine oxidase activity in liver and jejunum was markedly decreased (P < 0.
005 and P < 0.0005, respectively) in diabetic rats while the enzymic activity of kidney remained unchanged.
These results suggest the presence of multiple isomeric forms of molybdenum hydroxylases and some of these forms can be induced or suppressed by the diabetic inducing agent streptozotocin.
American Psychological Association (APA)
al-Bar, Umar Abd al-Rahman Mustafa. 2005. Activity changes of molybdenum hydroxylases in liver, kidney and jejunum of streptozotocin-induced diabetic rats. Journal of King Abdulaziz University : Sciences،Vol. 17, no. 1, pp.135-141.
https://search.emarefa.net/detail/BIM-364992
Modern Language Association (MLA)
al-Bar, Umar Abd al-Rahman Mustafa. Activity changes of molybdenum hydroxylases in liver, kidney and jejunum of streptozotocin-induced diabetic rats. Journal of King Abdulaziz University : Sciences Vol. 17, no. 1 ( 2005), pp.135-141.
https://search.emarefa.net/detail/BIM-364992
American Medical Association (AMA)
al-Bar, Umar Abd al-Rahman Mustafa. Activity changes of molybdenum hydroxylases in liver, kidney and jejunum of streptozotocin-induced diabetic rats. Journal of King Abdulaziz University : Sciences. 2005. Vol. 17, no. 1, pp.135-141.
https://search.emarefa.net/detail/BIM-364992
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 140
Record ID
BIM-364992