Sorafenib for egyptian patients with advanced hepatocellular carcinoma; single center experience

Abstract EN

According to the results of a number of phase 3 randomized studies, sorafenib is the only approved systemic therapy for advanced HCC; however the issue of high economic cost remains challenging ; thus we have conducted this retrospective analysis of our HCC patients treated with sorafenib.

Methods : HCC Shams University Hospitals, in the period between 2010 and 2012 were reviewed.

Eligible patients were those who had received sorafenib for advanced HCC not eligible for or progressed after surgery or locoregional therapy.

We investigated the impact of baseline clinicopathological factors (age, gender, child status, performance score, BCLC tumor stage, cause of chronic liver disease, median baseline alpha fetoprotein level and previous treatment received for HCC) on overall survival (OS) in an adjusted Cox regression model.

Results : 41 patients were included in the analysis fulfilling the inclusion criteria.

At a median follow up period of 13 months, the median PFS for the whole group was 4 months ; the median OS for the whole group is 6.25 months.

Multivariate analysis identified three baseline characteristics that were.