Pathological findings associated with experimental Mycobaterium bovis infection in rabbits

Abstract EN

During the 2nd week post inoculation of thirteen rabbits with Mycobacterium bovis tuberculosis lesions appeared in the lungs, liver, spleen, kidney, mediastinal and hepatic lymph nodes and in the omentum with an equal distribution in these organs.

During the 4th week post inoculation, these tuberculosis lesions increased in size to become well developed granulomas with caseated centers.

These granulomas persisted to the 6th, 8th and 10th weeks post inoculation and became more encapsulated later on.

Three rabbits died during the 7th week post inoculation due to generalized tuberculosis.