Associated autoimmune diseases in first degree relatives of type 1 diabetic children

Abstract EN

Type 1 diabetes mellitus (1 DM) resulting from im¬munological damage to pancreatic islets (cells is the most common immune-mediated, endocrine metabolic disorder in children with evidence suggesting that type 1 DM is a T-cell-mediated autoimmune disease.

About 5 % of people with a major polyendocrine autoimmune syndrome develop type 1DM.

Autoimmune thyroid disease is the most frequent autoimmune disease with type 1 DM.

An estimated 7 % of children with type 1 DM develop Celiac disease within six years of diagnosis.

To determine the prevalence of Celiac disease and thyroid disorders among children with type 1 DM, to¬gether with their first degree relatives, and to estimate the prevalence of DM among the first degree relatives of diabetic children, 300 type 1 DM children with 1950 first degree relatives were matched with 600 controls together with their 3,900 first degree relatives were screened in a case control study for autoimmune dis¬eases (Celiac disease, thyroid disorders) and the first degree relatives of cases and controls were screened for type 1 DM.

Celiac disease and thyroid disorders were insignifi¬cantly higher in cases than in controls.

Similar findings were seen in 1 st degree relatives of cases compared to controls, with a significant difference in Celiac disease.

Type 1DM prevalence was significantly higher in 1st degree relatives of cases than controls.

Conclusion : Target screening for Celiac disease and thyroid diseases in type 1 DM children is necessary, but screening 1st degree relatives of diabetic children for auto-immune diseases remains controversial.