Role of peptidoglycan in the pathogenesis of staphylococcus saprophyticus in mice

Abstract EN

The pathogenicity of S.

saprophyticus was studied in mice.

A group of white mice were injected transurethrally using a catheter with S.

saprophyticus S67 cell suspension in a concentration reached 109 CFU/ml.

concomitantly, the role of its peptidoglycan in the pathogenicity was studied by injecting another group of mice with 0.3 mg/0.2 ml of partially purified S.

saprophyticus S67 peptidoglycan extract.

After autopsy, kidneys and urinary bladder showed several histopathological changes both in cells and peptidoglycan injected mice, included: hydropic degeneration, glomerulus shrinkage, congestion of renal vessels, infiltration of inflammatory cells, and dekeratinization in urinary bladder.