Biological and phytochemical evaluation of two Sudanese plants of claimed hypoglycemic effect

Dissertant

Muhammad, Ahmad Ibrahim

Thesis advisor

Hasan, Abd al-Wahhab
Middawi, Mahmud

University

Omdurman Islamic University

Faculty

Faculty of Pharmacy

University Country

Sudan

Degree

Master

Degree Date

2011

English Abstract

The effects of ethanol extracts of Schouwia schimperi and Argemone Mexicana were investigated experimentally in glucose-loaded-rats, and streptozotocin induced-diabetic rats for their hypoglycemic activity and their impact on cholesterol and triglyceride levels. The ethanol extracts of the both plants were given at the doses of 200mg / kg and 400mg / kg body weight to glucose loaded wistar albino rats (2g / kg), and streptozotocin-induced- diabetic rats.

They caused significant reduction in plasma glucose levels (P < 0.05) at doses of 400 and 200 mg / kg Bwt.

in glucose loaded The effects Schouwia schimperi ethanol extract at the dose of 200 mg / kg were more prominent than those of glibenclamide which was taken as arefference standard.

Both extracts showed a significant reduction in cholesterol level (P < 0.05, p < .001), and Schouwia schimperi at the dose of 200 mg / kg reduced the triglycerides level significantly( p < .001). Also some phytochemical screening tests were made for these extracts and the results revealed that Argemone Mexicana contains high amounts of alkaloids, moderate quantities of deoxy-sugars and trace amounts of terpenoides, flavonoides and, tannins.

While schouwia schimperi contains high quantities of terpenoides, tannins and saponins besides moderate quantities of flavonoides and deoxy-sugars and trace amounts of alkaloids.

Main Subjects

Medicine

Topics

• Medicinal plants
• Diabetes
• Sudan
• Alternative medicine

No. of Pages

60

Table of Contents

• APA
• MLA
• AMA

Language

English

Data Type

Arab Theses

Record ID

BIM-367814