The relationship between serum sialic acid and humoral immune response in patients with asthma

Abstract EN

-Forty- six patients with asthma were tested for the serum levels of total sialic acid (TSA), Immunoglobulins (IgA, IgE, IgG, and TgM) and leukocyte counts (total and differential).

The results revealed a significant increased (P<0.0001) level of TSA in the sera of asthmatic patients (120.83 :L- 6.50 VS 69.80 ± 4.36; mg/dL) and such increase was associated with significant increases in the levels of IgA (248.73i56.45 w 64.70±!4.30;mg/dL), IgII (1483.16*484.97 w 30.33±8.21;IU/mL), IgG (1273.73*139.37 vs 572.60±51.3I;mg/dL) and IgM (i 87.38±22.60 v.s'38.18±5.21;mg/dL).

The data also showed non significant elevation in neutrophils, lymphocytes and monocytes.

However, eosinophils were an exception and a significant increase (P < 0.0001) was observed in the patients.

In conclusion, TSA could be a risk factor and a believe may be born that a modification of sialic acid residues might interfere with cell -cell recognition and interactions, which play a crucial role during immune