Carcinogenicity of cadmium chloride via intraperitoneal injection in albino rats

Abstract EN

In the present research, study was done on the carcinogenic effects of CdCl2 which Injected I/P in albino male rats.

The study includes determine LD50 of CdCl2 40 in albino male rats 6 weeks of ages which randomly divided into 4 equal groups and one of them left as control group, other 3 group injected I/P with CdCl2 at dose 30 mg/kg B.

Wt.

,23 mg /kg B.

Wt.

and 20 mg/kg B.

Wt.

for 24 hrs, 48 and 96 hrs.

The safe dose 10 mg/kg B.

Wt.

was used for I/P Injected to group chosen for which include 15 albino male rats and equal group used as control group, then the following parameters were studied : I .Cytogenetic investigation : include Micronuclei MN and chromosomal aberration which showen to be significantly Increase and mostly as breaks in chromosomes.

2.

Clinical signs: Vomation, bloody foamy cough , dyspnea and diarrhea in treated group were observed.

3.

Histopathological changes: lungs of treated rats showed grossly masses embedded and /or raised upon lung.

The masses diagnosed lately asadenocarcinoma which characterized by tubular or papullar form with acini formation which composed of columnar or cuboidal cells and vascularized connective tissue stalkes.

Emphysema and coagulation were also observed.