Synthes and characterization of Synthes and characterization of oxazepane and oxazepine from reaction of (5,5-Diethy l-4, 6-dioxo-tetrahydro-pyrimidin-2-ylidein)‎ thiourea and 1,3-Bis (5,5-Diethyl-4,6-dioxo-tetrahydro-pyrimidin-2-ylidein)‎ thiourea with maleic and succinic anhydride

Abstract EN

(5,5-Diethyl-4,6-dioxo-tetrahydro-pyrimidin-2-ylidein)-urea and 1,3-Bis(5,5-diethyl-4,6-dioxo-tetrahydro-pyrimidin-2-ylidein)- urea were prepared by condensation of urea with one equivalent and two equivalent of 5,5-Diethyl-pyrimidine-2,4,6-trione.

These Schiff-bases reacted with one equivalent of maleic and succinic anhydride in absolute ethanol to give 7-membered heterocyclic ring system of 3,3-Diethyl-2,4,8-tetraoxo-7-oxa-1,5,12-triaza-spiro [5.6] dodec-9-ene-12-carboxylic acid amide and were reacted with two equivalent of maleic and succinic anhydride in same solvent give doubled (7-membered) heterocyclic ring system of 12-(3,3-Diethyl-2,4,8,11-tetraoxo-7-oxa-1,5,12-triaza-spiro[5.6]dodecane-12-carbonoyl)-3-ethyl-3-methyl-7-oxa-1,5,12-triaza-spiro[5.6]dodec-9-ene-2,4,8,11-tetraone.