A new approach for the topical treatment of acne vulgaris by clindamycin HC1 supported on kaolin
Other Title(s)
طريقة جديدة للعلاج الموضعي لحب الشباب باستعمال الكلتدامايسين هيدروكلورايد المحمول على الكاؤلين
Joint Authors
Abd al-Husayn, Husayn Kazim
Isa, Sadun Abd al-Aziz
Jasim, Samir Mahmud
Source
Issue
Vol. 3, Issue 2 (30 Jun. 2006), pp.329-335, 7 p.
Publisher
University of Baghdad College of Science for Women
Publication Date
2006-06-30
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Abstract EN
Background4, the treatment of acne vulgaris should act against hyperkeratinization.
inflammation, bacterial proliferation and sebum production.
At the present, there is no topical anti-acne medication that acts against all of the above pathophysiologic features of acne.
The acne vulgaris response to the clindamycin is better than other available antibiotics, Kaolin by itself can be useful in sorption of bacteria, pus, toxins and free fatty acids.
Aim of the study: The aim of this work is to study the roie of the adsorption -desorption process in prolonging the action of the clindamycin drug .
Patients and Methods', adsorption of clindamycin HC! from 70% ethanol solution on different amounts of kaolin as adsorbent was studied using UV-spectrophotometry technique at 210nm.
Desorption process of the adsorbed clindamycin HC1 from kaolin surface was also studied.
Results: A stable formula consisting kaolin, clindamycin HC1 and 70% ethanol aqueous solution has been prepared for the treatment of acne vulgaris.
Conclusion'.
The formula provides prolonged action accompanied with a certain mechanism of clindamycin adsorbed on kaolin upon application on the skin leading to fairly good results in the treatment of acne vulgaris.
The mechanism of action of the formula is based on the adsorption-desorption processes of ihe aniibiotic on the clay.
American Psychological Association (APA)
Abd al-Husayn, Husayn Kazim& Isa, Sadun Abd al-Aziz& Jasim, Samir Mahmud. 2006. A new approach for the topical treatment of acne vulgaris by clindamycin HC1 supported on kaolin. Um-Salama Science Journal،Vol. 3, no. 2, pp.329-335.
https://search.emarefa.net/detail/BIM-368873
Modern Language Association (MLA)
Abd al-Husayn, Husayn Kazim…[et al.]. A new approach for the topical treatment of acne vulgaris by clindamycin HC1 supported on kaolin. Um-Salama Science Journal Vol. 3, no. 2 (2006), pp.329-335.
https://search.emarefa.net/detail/BIM-368873
American Medical Association (AMA)
Abd al-Husayn, Husayn Kazim& Isa, Sadun Abd al-Aziz& Jasim, Samir Mahmud. A new approach for the topical treatment of acne vulgaris by clindamycin HC1 supported on kaolin. Um-Salama Science Journal. 2006. Vol. 3, no. 2, pp.329-335.
https://search.emarefa.net/detail/BIM-368873
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 333-334
Record ID
BIM-368873