Effect of itraconazole and terbinafine on Leishmania major promastigotes

Abstract EN

The antiporliferative effect induced in vitro by two antifungal compounds, the azole itraconazole and the allylamine terbinafine on Leishmania major promastigotes are reported.

Treatment of promastigote cultures with itraconazole or with terbinafine induced growth arrest.

Concentrations of 0.75 μ / l or more of itraconazole induced cell lysis after 72 hours.

However, even relatively large concentrations of terbinafine (2.0 μ / l) did not induce cell lysis.

The IC 50 for itraconazole and terbinafine were 0.31 μl / l and 3.3 μl / l respectively.